State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China.
Adv Mater. 2017 Sep;29(36). doi: 10.1002/adma.201604878. Epub 2017 Aug 10.
Oleic acid (OA) and/or oleylamine (OAm) are generally used as the surface ligands for stabilization of inorganic nanocrystals (NCs). The hydrophobic and inert surface of the NCs limits their applications such as in biomedical areas. Hence, surface modifications are essential in many physical and chemical processes. Here, a facile and versatile strategy is reported for the modification of NCs by ultraviolet-induced thiol-ene chemistry, in which thiol-terminated poly(ethylene glycol) (HSPEG) and its derivatives can react directly with double bonds in OA/OAm ligands to form covalent linking within one step. Through this strategy, various hydrophobic NCs with different compositions and morphologies are able to be transferred into water combining with functionalization of active groups. As a proof-of-concept, this strategy is successfully used to construct a sensor for detecting avidin based on upconverting luminescence analysis. Therefore, this strategy provides a new tool for designing and tuning the surface properties of NCs for different applications.
油酸（OA）和/或油胺（OAm）通常被用作稳定无机纳米晶体（NCs）的表面配体。NCs 的疏水和惰性表面限制了它们在生物医学等领域的应用。因此，表面修饰在许多物理和化学过程中是必不可少的。在本文中，我们报告了一种通过紫外诱导的巯基-烯反应对 NCs 进行修饰的简便、通用的策略，其中巯基封端的聚乙二醇（HS-PEG）及其衍生物可以直接与 OA/OAm 配体中的双键反应，在一步中形成共价键连接。通过这种策略，各种具有不同组成和形貌的疏水 NCs 能够与活性基团的功能化相结合而转移到水中。作为概念验证，该策略成功地用于构建基于上转换发光分析的用于检测亲和素的传感器。因此，该策略为设计和调整不同应用的 NCs 的表面性能提供了新的工具。
