EU and OIE Reference Laboratory for Classical Swine Fever, Department of Infectious Diseases, Institute of Virology, University of Veterinary Medicine Hannover, Hannover, Germany.
Transbound Emerg Dis. 2018 May;65 Suppl 1:248-261. doi: 10.1111/tbed.12676. Epub 2017 Aug 10.
Classical swine fever (CSF) represents a major health and trade problem for the pig industry. In endemic countries or those with a wild boar reservoir, CSF remains a priority for Veterinary Services. Surveillance as well as stamping out and/or vaccination are the principle tools of prevention and control, depending on the context. In the past decades, marker vaccines and accompanying diagnostic tests allowing the discrimination of infected from vaccinated animals have been developed. In the European Union, an E2 subunit and a chimeric live vaccine have been licensed and are available for the use in future disease outbreak scenarios. The implementation of commonly accepted and globally harmonized concepts could pave the way to replace the ethically questionable stamping out policy by a vaccination-to-live strategy and thereby avoid culling of a large number of healthy animals and save food resources. Although a number of vaccines and diagnostic tests are available worldwide, technological advancement in both domains is desirable. This work provides a summary of an analysis undertaken by the DISCONTOOLS group of experts on CSF. Details of the analysis can be downloaded from the web site at http://www.discontools.eu/.
古典猪瘟（Classical swine fever，CSF）对养猪业的健康和贸易构成了重大威胁。在地方性流行国家或存在野猪疫源的国家，兽医服务机构仍将其视为优先事项。监测以及扑杀和/或免疫接种是预防和控制的主要手段，具体取决于具体情况。在过去的几十年中，已经开发出了标记疫苗和伴随的诊断测试，可以区分感染动物和接种疫苗的动物。在欧盟，已经批准了 E2 亚单位和嵌合活疫苗，可用于未来的疾病爆发情况。实施普遍接受和全球协调一致的概念，可以为取代具有伦理问题的扑杀政策铺平道路，转而采用接种疫苗以维持猪群生存的策略，从而避免大量健康动物被扑杀，并节约食物资源。尽管全世界有许多疫苗和诊断检测方法，但这两个领域的技术进步都是可取的。这项工作总结了 DISCONTOOLS 专家组对 CSF 的分析。分析的详细信息可以从网站 http://www.discontools.eu/ 下载。
