a Department of Public Health , Universidade Federal de Santa Catarina , Florianópolis , Brazil.
b Department of Medicine , Universidade do Sul de Santa Catarina , Palhoça , Brazil.
Aging Ment Health. 2018 Nov;22(11):1525-1533. doi: 10.1080/13607863.2017.1360840. Epub 2017 Aug 10.
Dementia is expected to affect one million individuals in the United Kingdom by 2025; its prodromal phase may start decades before its clinical onset. The aim of this study is to investigate whether use of internet from 50 years of age is associated with a lower incidence of dementia over a ten-year follow-up.
We analysed data based on 8,238 dementia free (at baseline in 2002-2004) core participants from the English Longitudinal Study of Ageing. Information on baseline use of internet was obtained through questionnaires; dementia casesness was based on participant (or informant) reported physician diagnosed dementia or overall score on the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE). Cox proportional hazards regression analysis was used for examining the relationship between internet use and incident dementia.
There were 301 (5.01%) incident dementia cases during the follow-up. After full multivariable adjustment for potential confounding factors, baseline internet use was associated with a 40% reduction in dementia risk assessed between 2006-2012 (HR = 0.60 CI: 0.42-0.85; p < 0.05).
This study suggests that use of internet by individuals aged 50 years or older is associated with a reduced risk of dementia. Additional studies are needed to better understand the potential causal mechanisms underlying this association.
到 2025 年，预计英国将有 100 万人受到痴呆症的影响；其前驱期可能在其临床发病前几十年开始。本研究旨在探讨从 50 岁开始使用互联网是否与十年随访期间痴呆症发病率降低有关。
我们分析了来自英国老龄化纵向研究的 8238 名无痴呆症（基线时在 2002-2004 年）核心参与者的数据。通过问卷获取基线使用互联网的信息；痴呆病例的确定基于参与者（或知情人）报告的医生诊断痴呆或老年认知障碍询问表（IQCODE）的总得分。使用 Cox 比例风险回归分析检查互联网使用与新发痴呆症之间的关系。
在随访期间，有 301 例（5.01%）新发痴呆症病例。在对潜在混杂因素进行充分多变量调整后，基线时使用互联网与痴呆风险降低 40%相关，评估时间为 2006-2012 年（HR=0.60，CI：0.42-0.85；p<0.05）。
本研究表明，50 岁或以上的个体使用互联网与痴呆风险降低有关。需要进一步的研究来更好地理解这种关联的潜在因果机制。
