Carbone Salvatore, Popovic Dejana, Lavie Carl J, Arena Ross
VCU Pauley Heart Center - Virginia Commonwealth University West Hospital - 5th Floor, Room 520 1200 E Broad Street, PO Box 980204, Richmond, VA 23298, USA.
Victoria Johnson Research Laboratories, Virginia Commonwealth University, Richmond, VA 23298, USA.
Future Cardiol. 2017 Sep;13(5):451-463. doi: 10.2217/fca-2017-0023. Epub 2017 Aug 10.
Obesity is defined as an excess body fat that impairs health and is associated with increased risk of heart failure (HF), particularly HF with preserved ejection fraction (HFpEF), evolving into a 'HFpEF obesity phenotype'. The interplay between obesity and cardiorespiratory fitness, primary clinical parameters in HF, requires further exploration. The contribution of body composition compartments in the development and progress of HF has been the object of numerous studies. Here we focus on how fat mass and lean tissues affect cardiorespiratory fitness, with emphasis on their effects on peak oxygen consumption. Moreover, while several studies have focused on characterization of body composition compartments, here we describe also recent findings related to abnormal and/or dysfunctional lean mass, especially in HFpEF.
肥胖被定义为损害健康的体内脂肪过多，并且与心力衰竭（HF）风险增加相关，尤其是射血分数保留的心力衰竭（HFpEF），进而演变成“HFpEF肥胖表型”。肥胖与心肺适能（HF的主要临床参数）之间的相互作用需要进一步探索。身体成分各部分在HF发生和发展中的作用一直是众多研究的对象。在此，我们关注脂肪量和瘦组织如何影响心肺适能，重点是它们对峰值耗氧量的影响。此外，虽然有几项研究专注于身体成分各部分的特征描述，但在此我们也描述了与异常和/或功能失调的瘦体重相关的最新发现，尤其是在HFpEF中。
