Wang Jia, Xie Yanming, Zhao Shitong, Zhang Jiangsong, Chai Yan, Li Yuanyuan, Liao Xing
Institute of Basic Research in Clinical Medicine Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences Beijing University of Chinese Medicine, Beijing Zhejiang University of Traditional Chinese Medicine, Zhejiang, China Department of Epidemiology, University of California-Los Angeles, CA.
Medicine (Baltimore). 2017 Aug;96(32):e7674. doi: 10.1097/MD.0000000000007674.
No systematic review has been published in English of Dengzhanxixin (DZXX) injection for cerebral infarction. The aim of this systematic review was to assess the effects and safety of DZXX injection for cerebral infarction.
Eight databases were searched from their inception. Randomized controlled trials (RCTs) related to DZXX for cerebral infarction in English or Chinese without restrictions on the publication status were included. Neurological deficit, quality of life, and response rates were analyzed. Adverse events were also investigated.
Twenty-three randomized controlled trials (RCTs) with 2291 participants were included. Meta-analysis showed that DZXX injection plus routine western therapy was better than routine western therapy alone for reducing neurologic deficit (MD -2.86, 95% CI -3.87 to -1.86), for improving quality of life (MD 9.48, 95% CI 8.34-10.63), and for improving response rates (RR 1.20, 95% CI 1.15-1.25). No serious adverse drug events (ADE) were reported.
DZXX injection may have a potential therapeutic effect for cerebral infarction in reducing neurologic deficit, improving life quality and response rates. However, we could not draw any definitive conclusions due to the insufficient evidences. More high-quality trials are needed to provide more strong evidence and to assess the safety of DZXX injection.
尚无英文发表的关于灯盏细辛注射液治疗脑梗死的系统评价。本系统评价旨在评估灯盏细辛注射液治疗脑梗死的疗效和安全性。
检索8个数据库自建库以来的文献。纳入英文或中文发表的、与灯盏细辛治疗脑梗死相关的随机对照试验（RCT），对发表状态无限制。分析神经功能缺损、生活质量及有效率，并调查不良事件。
纳入23项随机对照试验，共2291例受试者。Meta分析显示，灯盏细辛注射液联合西医常规治疗在减轻神经功能缺损（MD -2.86，95%CI -3.87至-1.86）、改善生活质量（MD 9.48，95%CI 8.34 - 10.63）及提高有效率（RR 1.20，95%CI 1.15 - 1.25）方面均优于单纯西医常规治疗。未报告严重药物不良事件。
灯盏细辛注射液可能对脑梗死具有潜在治疗作用，可减轻神经功能缺损、改善生活质量及提高有效率。然而，由于证据不足，我们无法得出任何确切结论。需要更多高质量试验以提供更有力证据并评估灯盏细辛注射液的安全性。
