Hu Jia, Shen Hui, Chu Guang-Ping, Fu Han, Huang Fei-Fei, Zheng Yan-Min, Han Di, Zhou Yi-Kai, Wang Qi, Wang Bo, Teng Chen-Gang, Liu Fang, Yang Hai-Bing
Suzhou Center for Disease Prevention and Control Health Center for Women and Children of Gusu District, Suzhou, Jiangsu Xi'an Center for Disease Control and Prevention, Xi'an, Shaanxi Province MOE Key Lab of Environment and Health, Institute of Environmental Medicine Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Medicine (Baltimore). 2017 Aug;96(32):e7696. doi: 10.1097/MD.0000000000007696.
Elevated resting heart rate (RHR) or resting pulse rate (RPR) is associated with increased risk of hypertension development. However, information is limited to adults. The purpose of this study is to analyze this association among Chinese children in a prospective design.
A total of 4861 children who participated in the Blood Pressure Surveillance Program (2011-2017) were selected in this research. To investigate the association between RPR and hypertension development, children were divided into 4 groups according to the quartiles of RPR at baseline. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using logistic regression model.
Over a mean follow-up of 3.0 ± 0.1 years, there were 384 cases of incident hypertension. Compared to boys and girls in the 1st quartile, those in the 4th quartile were 1.73 (95% CI 1.13, 2.65), 2.22 (95% CI 1.43, 3.45) times more likely to have hypertension, respectively. Every 10 bpm increase in RPR was associated with a 26% greater risk of hypertension development in boys (OR: 1.26; 95% CI 1.10, 1.44), while this risk was 1.28 (95% CI 1.13, 1.44) in girls. Baseline blood pressure (BP) and body mass index (BMI) did not have significant interactions with RPR on risk of hypertension development.
This study confirms the relationship between elevated RPR and increased risk of hypertension development in children, independent of confounders including baseline BP and BMI. An elevated RPR could be considered as a risk factor for the assessment of hypertension, no matter from a clinical setting or a public health perspective.
静息心率（RHR）或静息脉率（RPR）升高与高血压发病风险增加相关。然而，相关信息仅限于成年人。本研究的目的是以前瞻性设计分析中国儿童中的这种关联。
本研究选取了4861名参与血压监测项目（2011 - 2017年）的儿童。为了研究RPR与高血压发病之间的关联，根据基线时RPR的四分位数将儿童分为4组。使用逻辑回归模型计算比值比（OR）及其95%置信区间（CI）。
在平均3.0±0.1年的随访期内，有384例新发高血压病例。与第1四分位数的男孩和女孩相比，第4四分位数的男孩和女孩患高血压的可能性分别高1.73倍（95%CI 1.13，2.65）、2.22倍（95%CI 1.43，3.45）。RPR每增加10次/分钟，男孩患高血压的风险增加26%（OR：1.26；95%CI 1.10，1.44），而女孩的这一风险为1.28（95%CI 1.13，1.44）。基线血压（BP）和体重指数（BMI）在高血压发病风险方面与RPR没有显著交互作用。
本研究证实了RPR升高与儿童高血压发病风险增加之间的关系，独立于包括基线BP和BMI在内的混杂因素。无论从临床还是公共卫生角度来看，RPR升高都可被视为评估高血压的一个风险因素。
