Pham Tho X, Lee Ji-Young
Department of Nutritional Sciences, University of Connecticut, 216 Advanced Technology Laboratory Building, 1392 Storrs Road, Storrs, CT 06269, USA.
Department of Nutritional Sciences, University of Connecticut, 211C Advanced Technology Laboratory Building, 1392 Storrs Road, Storrs, CT 06269, USA.
Int J Mol Sci. 2017 Aug 10;18(8):1740. doi: 10.3390/ijms18081740.
Adipose tissue expansion in obesity leads to changes in the expression of adipokines, adipocyte-specific hormones that can regulate whole body energy metabolism. Epigenetic regulation of gene expression is a mechanism by which cells can alter gene expression through the modifications of DNA and histones. Epigenetic mechanisms, such as DNA methylation and histone modifications, are intimately tied to energy metabolism due to their dependence on metabolic intermediates such as S-adenosylmethionine and acetyl-CoA. Altered expression of adipokines in obesity may be due to epigenetic changes. The goal of this review is to highlight current knowledge of epigenetic regulation of adipokines.
肥胖状态下脂肪组织的扩张会导致脂肪因子表达的变化，脂肪因子是一类可调节全身能量代谢的脂肪细胞特异性激素。基因表达的表观遗传调控是一种细胞可通过DNA和组蛋白修饰来改变基因表达的机制。表观遗传机制，如DNA甲基化和组蛋白修饰，由于其对S-腺苷甲硫氨酸和乙酰辅酶A等代谢中间体的依赖性，与能量代谢密切相关。肥胖状态下脂肪因子表达的改变可能是由于表观遗传变化所致。本综述的目的是强调目前关于脂肪因子表观遗传调控的知识。
