Ho Jonathan D, Kam Sarah A, Al-Haseni Ali, Markova Alina, Sahni Debjani, Lam Christina, Goldberg Lynne J, Bhawan Jag
Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts.
Department of Pathology & Laboratory Medicine, Boston University, Boston, Massachusetts.
J Cutan Pathol. 2017 Nov;44(11):969-973. doi: 10.1111/cup.13022. Epub 2017 Sep 4.
Epidermodysplasia verruciformis (EV) is a genodermatosis characterized by overgrowth of flat warts, pityriasis versicolor-like lesions and an increased propensity for developing cutaneous squamous cell carcinomas due to abnormal susceptibility to infection with beta-human papilloma viruses. Adnexal tumors are not typically associated with EV. Here we report a spectrum of hybrid adnexal tumors with divergent eccrine and folliculosebaceous differentiation, and cytologic features ranging from benign to frankly atypical, in a patient with inherited EV.
疣状表皮发育不良（EV）是一种遗传性皮肤病，其特征为扁平疣过度增生、花斑癣样损害，以及由于对β-人乳头瘤病毒感染异常易感而导致皮肤鳞状细胞癌发生倾向增加。附属器肿瘤通常与EV无关。在此，我们报告了1例遗传性EV患者出现一系列具有不同汗腺和毛囊皮脂腺分化的混合性附属器肿瘤，其细胞学特征从良性到明显非典型。
