胃肠道肽类物质诱发绵羊肝胆汁和胰腺外分泌

Hepatic bile and pancreatic exocrine secretions evoked by gastrointestinal peptides in sheep.

作者信息

Harada E, Niiyama M, Syuto B

出版信息

Comp Biochem Physiol A Comp Physiol. 1986;85(4):729-34. doi: 10.1016/0300-9629(86)90285-9.

Abstract

The secretory response of hepatic bile and exocrine pancreas to gastrointestinal peptides has been studied in chronically cannulated sheep. Pancreatic juice flow and protein output were evoked dose dependently by intraportal injection of secretin, CCK-8, caerulein, VIP and neurotensin. However, biliary secretion was evoked by only secretin. Biliary and pancreatic exocrine secretions were enhanced by delivered gastric juice into the duodenum as followed by the increased plasma concentration of immunoreactive secretin (IRS). Results suggest that secretin is the major peptide that regulates pancreatic exocrine secretion and hepatic bile production in the sheep.

摘要

在长期插管的绵羊身上研究了肝胆汁和胰腺外分泌对胃肠肽的分泌反应。通过门静脉内注射促胰液素、胆囊收缩素-8、蛙皮素、血管活性肠肽和神经降压素，胰液分泌量和蛋白质分泌量呈剂量依赖性增加。然而，仅促胰液素能引起胆汁分泌。将胃液注入十二指肠后，胆汁和胰腺外分泌增加，同时血浆中免疫反应性促胰液素（IRS）浓度升高。结果表明，促胰液素是调节绵羊胰腺外分泌和肝胆汁生成的主要肽类。