猪和鸡的血管活性肠肽对禽类外分泌胰腺有强烈刺激作用。

Potent stimulation of the avian exocrine pancreas by porcine and chicken vasoactive intestinal peptide.

作者信息

Dimaline R, Dockray G J

出版信息

J Physiol. 1979 Sep;294:153-63. doi: 10.1113/jphysiol.1979.sp012922.

DOI:10.1113/jphysiol.1979.sp012922

PMID:512939

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1280549/

Abstract

The actions of chicken and porcine secretins and vasoactive intestinal peptides (VIPs) were compared on the rate of flow and rate of protein secretion from the exocrine pancreas in urethane anaesthetized turkeys and rats. 2. Chicken VIP was about twice as potent as porcine VIP and 100-150 times as potent as chicken and porcine secretins in stimulating the flow of pancreatic juice in the turkey. 3. Porcine secretin was a strong stimulant of the flow of pancreatic juice in the rat, but chicken secretin and the two VIPs were only active in doses 20-50 times higher than those of porcine secretin. 4. Neither the two VIPs nor the two secretins significantly stimulated the rate of pancreatic protein secretion in the turkey or rat. 5. In the turkey I.V. infusion of graded doses of chicken VIP produced graded increases in the flow of pancreatic juice; in the presence of an infusion of a low dose of CCK8 the flow of juice secreted in response to the highest dose of chicken VIP was significantly lower compared with the infusion of VIP alone, and responses to the other doses of VIP were lower but not significantly so. The infusion of chicken secretin reduced the flow of juice in response to infusions of chicken VIP, but the differences were not significant. There was no significant difference in either the rate of flow, or rate of protein secretion from the turkey pancreas in response to an infusion of chicken secretin and CCK8, compared with CCK8 alone. 6. The results cast doubt on the importance of secretin for regulation of the avian pancreas, and suggest instead that VIP might have a physiological role in regulating the flow of pancreatic juice in birds.

摘要

在氨基甲酸乙酯麻醉的火鸡和大鼠中，比较了鸡和猪促胰液素及血管活性肠肽（VIP）对胰腺外分泌的流量和蛋白质分泌速率的作用。2. 鸡VIP在刺激火鸡胰液分泌方面的效力约为猪VIP的两倍，是鸡和猪促胰液素的100 - 150倍。3. 猪促胰液素是大鼠胰液分泌的强效刺激物，但鸡促胰液素和两种VIP仅在比猪促胰液素高20 - 50倍的剂量下才有活性。4. 两种VIP和两种促胰液素均未显著刺激火鸡或大鼠的胰腺蛋白质分泌速率。5. 在火鸡中，静脉输注不同剂量的鸡VIP会使胰液流量呈梯度增加；在输注低剂量CCK8的情况下，与单独输注VIP相比，对最高剂量鸡VIP分泌的胰液流量显著降低，对其他剂量VIP的反应较低但不显著。输注鸡促胰液素会降低对鸡VIP输注的胰液流量，但差异不显著。与单独输注CCK8相比，输注鸡促胰液素和CCK8时火鸡胰腺的流量或蛋白质分泌速率均无显著差异。6. 这些结果对促胰液素在调节禽类胰腺方面的重要性提出了质疑，相反表明VIP可能在调节鸟类胰液流量中具有生理作用。