Konturek S J, Król R, Dembiński A, Wünsch E
Pflugers Arch. 1976 Aug 24;364(3):297-300. doi: 10.1007/BF00581768.
Motilin and secretin were compared in regard to their effects on pancreatic bicarbonate and protein secretion in conscious dogs provided with chronic pancreatic fistulas. Dose-response analysis showed that maximal bicarbonate response to motilin was about 5% of that to secretin and maximal protein response was about 35% of that to caerulein. The interaction of these two peptides showed that motilin is a potent inhibitor of secretin-induced bicarbonate secretion. Since motilin is released by duodenal alkalinization and inhibits pancreatic bicarbonate secretion, it is possible that this peptide is involved in the feedback mechanism of inhibition of pancreatic secretion by alkaline pancreatic juice present in the duodenum.
在具有慢性胰瘘的清醒犬中，比较了胃动素和促胰液素对胰腺碳酸氢盐和蛋白质分泌的影响。剂量反应分析表明，胃动素引起的最大碳酸氢盐反应约为促胰液素的5%，最大蛋白质反应约为蛙皮素的35%。这两种肽的相互作用表明，胃动素是促胰液素诱导的碳酸氢盐分泌的有效抑制剂。由于胃动素由十二指肠碱化释放并抑制胰腺碳酸氢盐分泌，因此该肽可能参与十二指肠中存在的碱性胰液对胰腺分泌的反馈抑制机制。
