Chiu W T, Lin L S, Shih C J, Lin M T
Exp Neurol. 1987 Feb;95(2):368-77. doi: 10.1016/0014-4886(87)90145-2.
The thermal responses of rats which were pretreated with 5,7-dihydroxytryptamine to deplete hypothalamic 5-hydroxytryptamine, 6-hydroxydopamine to deplete hypothalamic catecholamines, phentolamine and propranolol to inhibit adrenergic receptors, haloperidol to inhibit dopamine receptors, or atropine to inhibit cholinergic receptors, to intrahypothalamic administration of bombesin were compared with those of control rats. The bombesin-induced hypothermia was attenuated by pretreatment of the rats with either hypothalamic dopamine depletion or receptor blockade, or hypothalamic cholinergic receptor blockade. The reduction in the bombesin-induced hypothermia in the treated rats was due to the reduction of metabolic and vasomotor response. The data indicate that bombesin may act on hypothalamic dopamine and/or cholinergic receptor mechanisms to induce hypothermia by promoting a reduction in metabolic heat production and an enhancement in heat loss in rats.
将用5,7-二羟基色胺预处理以耗尽下丘脑5-羟色胺、用6-羟基多巴胺预处理以耗尽下丘脑儿茶酚胺、用酚妥拉明和普萘洛尔抑制肾上腺素能受体、用氟哌啶醇抑制多巴胺受体或用阿托品抑制胆碱能受体的大鼠对下丘脑内注射蛙皮素的热反应与对照大鼠的热反应进行了比较。蛙皮素诱导的体温过低通过用下丘脑多巴胺耗竭或受体阻断，或下丘脑胆碱能受体阻断对大鼠进行预处理而减弱。处理过的大鼠中蛙皮素诱导的体温过低的降低是由于代谢和血管运动反应的降低。数据表明，蛙皮素可能作用于下丘脑多巴胺和/或胆碱能受体机制，通过促进大鼠代谢产热减少和散热增加来诱导体温过低。
