Liu H J, Lin M T
Pharmacology. 1985;31(2):108-14. doi: 10.1159/000138105.
The thermal effects of rats which were pretreated with 5,7-dihydroxytryptamine to deplete hypothalamic 5-hydroxytryptamine (5-HT) or with a 5-HT receptor blocker to intrahypothalamic administration of cholecystokinin (CCK) were compared with those of control rats. The CCK-induced hypothermic response was attenuated by pretreatment of the rats with either hypothalamic 5-HT depletion or receptor blockade. The reduction in the CCK hypothermia in the treated rats was due to the reduction of metabolic and vasomotor response. The data indicate that CCK may act on a 5-HT pathway within the hypothalamus to induce its hypothermia by promoting a reduction in metabolic heat production and an enhancement in heat loss in rats.
将用5,7 - 二羟基色胺预处理以耗尽下丘脑5 - 羟色胺（5 - HT）或用5 - HT受体阻滞剂对下丘脑内注射胆囊收缩素（CCK）的大鼠的热效应与对照大鼠进行比较。用下丘脑5 - HT耗竭或受体阻断预处理大鼠后，CCK诱导的体温过低反应减弱。处理组大鼠CCK诱导的体温过低的降低是由于代谢和血管运动反应的降低。数据表明，CCK可能作用于下丘脑内的5 - HT途径，通过促进大鼠代谢产热减少和散热增加来诱导体温过低。
