造血干细胞移植受者和血液恶性肿瘤患者的真菌感染。
Fungal Infections of the Stem Cell Transplant Recipient and Hematologic Malignancy Patients.
机构信息
Department of Internal Medicine, University of California Davis Medical Center, 4150 V Street, Suite 3100, Sacramento, CA 95817, USA.
Department of Internal Medicine, Division of Infectious Diseases, University of California Davis Medical Center, 4150 V Street, Suite G500, Sacramento, CA 96817, USA; Department of Medical Microbiology and Immunology, University of California - Davis, One Shields Avenue, Tupper Hall, Davis, CA 95616, USA.
出版信息
Infect Dis Clin North Am. 2019 Jun;33(2):545-566. doi: 10.1016/j.idc.2019.02.006.
Despite advances in chemotherapy and supportive care, morbidity and mortality remain high for patients with hematologic malignancies (HMs). Those who require hematopoietic stem cell transplantation (HSCT) often require significant immunosuppression and are subject to a variety of complications. These patients carry multiple risk factors for infectious complications, including the development of invasive fungal infections, compared with the general population. Because antifungal prophylaxis has been widely adopted, there has been a shift away from invasive candidiasis toward invasive mold infections, including breakthrough infections. For patients with HM and HSCT, we outline the epidemiology, manifestations, diagnosis, and treatment of invasive fungal infections.
尽管化疗和支持性治疗取得了进展，但血液系统恶性肿瘤（HMs）患者的发病率和死亡率仍然很高。那些需要造血干细胞移植（HSCT）的患者通常需要大量的免疫抑制治疗，并且容易出现多种并发症。与普通人群相比，这些患者存在多种感染并发症的危险因素，包括侵袭性真菌感染的发生。由于抗真菌预防措施已被广泛采用，侵袭性念珠菌病的发病率已下降，而侵袭性霉菌感染（包括突破性感染）的发病率则有所上升。对于血液系统恶性肿瘤和造血干细胞移植的患者，我们概述了侵袭性真菌感染的流行病学、表现、诊断和治疗。
Zotero 插件