Fouad Ali, Marzouk Adel A, Ibrahim Samy M, El-Adl Sobhy M, Ghanem Ashraf
Chirality Program, Faculty of ESTEM, University of Canberra, ACT, 2601, Australia; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
J Chromatogr A. 2017 Sep 15;1515:91-99. doi: 10.1016/j.chroma.2017.07.065. Epub 2017 Jul 23.
Here we report the first encapsulation of three carbamylated amylose namely R-, S- and R/S-amylose 2,3(3,5-dimethylphenylcarbamate)-6-ethylphenylcarbamate in organic polymer monolith in situ capillary columns. The columns were investigated for the enantioselective nano-liquid chromatographic separation of a set of racemic pharmaceuticals, namely, α- and β-blockers, anti-inflammatory drugs, antifungal drugs, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, antihistaminics, anticancer drugs, and antiarrhythmic drugs. Baseline separation was achieved for several drugs under reversed phase chromatographic conditions and only few drugs were separated under normal phase conditions. The developed columns provide more economical analysis under environmentally benign conditions.
在此，我们报道了三种氨甲酰化直链淀粉，即R-、S-和R/S-直链淀粉2,3(3,5-二甲基苯基氨基甲酸酯)-6-乙基苯基氨基甲酸酯首次被包封于有机聚合物整体柱原位毛细管柱中。对这些色谱柱进行了研究，用于一组外消旋药物的对映体选择性纳米液相色谱分离，这些药物包括α-和β-阻滞剂、抗炎药、抗真菌药、去甲肾上腺素-多巴胺再摄取抑制剂、儿茶酚胺、镇静催眠药、抗组胺药、抗癌药和抗心律失常药。在反相色谱条件下，几种药物实现了基线分离，而在正相条件下仅分离出少数几种药物。所开发的色谱柱在环境友好的条件下提供了更经济的分析方法。
