Cardiology Division, Electrophysiology Section, University of Minnesota, Minneapolis, MN.
Cardiology Division, Electrophysiology Section, University of Minnesota, Minneapolis, MN.
Trends Cardiovasc Med. 2018 Jan;28(1):53-61. doi: 10.1016/j.tcm.2017.07.009. Epub 2017 Aug 1.
Atrial arrhythmias are a common complication after lung transplant (LT), occurring in about 16-46% of LT patients early postoperatively, and in about 14% during longer-term follow-up. They have a significant impact on postoperative in-hospital length of stay and may have an impact on overall mortality. In this report, we review the incidence and risk factors of post lung transplant AA, their pathogenesis and their impact on short- and long-term outcomes. Pharmacological management options are reviewed. In brief, early atrial arrhythmias tend to be mostly atrial fibrillation and are treated acutely with a rate control strategy followed if needed by rhythm control for 4-6 weeks. Late atrial arrhythmias >6 months after LT tend to be more frequently organized atrial flutters amenable to ablation therapy. Long-term anticoagulation is controversial especially in patients with bilateral lung transplant who received surgical pulmonic vein isolation, however anticoagulation is still favored especially in single LT patients. More studies are needed to further document the pathophysiology of early versus late atrial arrhythmias and whether long-term anticoagulation is needed.
心房颤动是肺移植(LT)后的常见并发症,约 16-46%的 LT 患者在术后早期发生,约 14%在长期随访中发生。它们对术后住院时间有显著影响,可能对总体死亡率有影响。在本报告中,我们回顾了 LT 后 AA 的发生率和危险因素、发病机制及其对短期和长期结局的影响。我们还回顾了药物治疗的选择。简而言之,早期的心房颤动通常是心房颤动,急性发作时采用控制心室率的策略,如果需要,可在 4-6 周后转为控制节律。LT 后 6 个月以上的晚期心房颤动往往更常发生可进行消融治疗的有组织的心房扑动。长期抗凝治疗存在争议,尤其是在接受外科肺静脉隔离的双侧肺移植患者中,但抗凝治疗仍被推荐,特别是在单侧 LT 患者中。需要进一步开展更多研究以进一步记录早期与晚期心房颤动的病理生理学,以及是否需要长期抗凝治疗。