Sunder Thirugnanasambandan, Ramesh Paul, Kumar Madhan
Department of Heart Lung Transplantation and Mechanical Circulatory Support, Apollo Hospitals, Chennai 600086, Tamil Nadu, India.
World J Transplant. 2025 Jun 18;15(2):101005. doi: 10.5500/wjt.v15.i2.101005.
Lung transplantation (LT) is now an accepted therapy for end stage lung disease in appropriate patients. Atrial arrhythmias (AA) can occur after LT. Early AA after LT are most often atrial fibrillation, whereas late arrhythmias which occur many months or years after LT are often atrial tachycardia. The causes of AA are multifactorial. The review begins with a brief history of LT and AA. This review further describes the pathophysiology of the AA. The risk factors, incidence, recipient characteristics including intra-operative factors are elaborated on. Since there are no clear and specific guidelines on the management of atrial arrhythmia following LT, the recommended guidelines on the management of AA in general are often extrapolated and used in the setting of post LT arrhythmia. The strategy of rate control rhythm control is discussed. The pros and cons of various drug regimen, need for direct current cardioversion and catheter ablation therapies are considered. Possible methods to prevent or reduce the incidence of AA after LT are considered. The impact of AA on the short-term and long-term outcomes following LT is discussed.
肺移植(LT)现已成为适合患者终末期肺病的一种公认治疗方法。肺移植后可发生房性心律失常(AA)。肺移植后的早期房性心律失常最常见的是房颤,而肺移植数月或数年之后发生的晚期心律失常通常是房性心动过速。房性心律失常的病因是多因素的。本文综述首先简要介绍肺移植和房性心律失常的历史。本综述进一步描述了房性心律失常的病理生理学。阐述了危险因素、发病率、受者特征包括术中因素。由于肺移植后房性心律失常的管理尚无明确和具体的指南,一般推荐的房性心律失常管理指南通常被外推并用于肺移植后心律失常的情况。讨论了心率控制与节律控制策略。考虑了各种药物治疗方案的利弊、直流电复律和导管消融治疗的必要性。探讨了预防或降低肺移植后房性心律失常发生率的可能方法。讨论了房性心律失常对肺移植后短期和长期预后的影响。