口服肠道去定植对异基因造血干细胞移植患者金黄色葡萄球菌定植的影响。
Impact of oral gut decontamination on Staphylococcus aureus colonisation in patients undergoing allogeneic haematopoietic stem cell transplantation.
机构信息
Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
出版信息
Int J Antimicrob Agents. 2017 Dec;50(6):726-729. doi: 10.1016/j.ijantimicag.2017.08.008. Epub 2017 Aug 7.
Recipients of allogeneic haematopoietic stem cell transplantation (allo-HSCT) are severely immunocompromised and are at increased risk of infection. In this prospective, observational, single-centre study including 110 allo-HSCT recipients, the rate of Staphylococcus aureus colonisation was reduced from 11.8% to 0% (P <0.001) following peritransplant oral gut decontamination. No invasive S. aureus infections were observed.
异基因造血干细胞移植（allo-HSCT）受者的免疫功能严重受损，感染风险增加。在这项包括 110 例 allo-HSCT 受者的前瞻性、观察性、单中心研究中，移植前口腔肠道去污使金黄色葡萄球菌定植率从 11.8%降至 0%（P<0.001）。未观察到侵袭性金黄色葡萄球菌感染。
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