Jabłońska Anna, Richert-Przygońska Monika, Jaremek Kamila, Czyżewski Krzysztof, Badowska Wanda, Balwierz Walentyna, Bień Ewa, Brzeski Tomasz, Chaber Radosław, Czogała Wojciech, Dembowska-Bagińska Bożenna, Derwich Katarzyna, Drabko Katarzyna, Dzierżanowska-Fangrat Katarzyna, Frączkiewicz Jowita, Gietka Agnieszka, Goździk Jolanta, Gryniewicz-Kwiatkowska Olga, Hutnik Łukasz, Irga-Jaworska Ninela, Kałwak Krzysztof, Karolczyk Grażyna, Królak Aleksandra, Łaguna Pawel, Machnik Katarzyna, Mańko-Glińska Hanna, Mizia-Malarz Agnieszka, Młynarski Wojciech, Musiał Jakub, Mycko Katarzyna, Ociepa Tomasz, Pająk Sonia, Peregud-Pogorzelski Jarosław, Pierlejewski Filip, Płonowski Marcin, Salamonowicz-Bodzioch Małgorzata, Sawicka-Żukowska Małgorzata, Semczuk Katarzyna, Skowron-Kandzia Katarzyna, Stolpa Weronika, Szczepański Tomasz, Szmydki-Baran Anna, Tomaszewska Renata, Urasiński Tomasz, Urbanek-Dądela Agnieszka, Urbańska-Rakus Justyna, Wawryków Paweł, Zając-Spychała Olga, Zalas-Więcek Patrycja, Zaucha-Prażmo Agnieszka, Zawitkowska Joanna, Żak Iwona, Styczyński Jan
Doctoral School of Medical and Health Sciences, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 85-067 Bydgoszcz, Poland.
Department of Paediatric Haematology and Oncology, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 85-094 Bydgoszcz, Poland.
J Clin Med. 2025 Jul 22;14(15):5200. doi: 10.3390/jcm14155200.
: spp. represent the most prevalent Gram-positive organisms in children with malignancies or undergoing haematopoietic cell transplantation (HCT), contributing to significant morbidity and mortality. This study aimed to assess the epidemiology, risk factors, treatment strategies, and outcomes of staphylococcal infections (SIs) in paediatric haemato-oncology (PHO) and HCT patients in Poland over a 12-year period. : A retrospective, multicentre study was conducted across 17 paediatric oncology centres in Poland. The clinical and microbiological data of patients under the age of 18, diagnosed with malignancies or post-HCT, were analysed for confirmed SI between 2012 and 2023. The variables assessed included demographics, underlying conditions, infection type and source, antimicrobial susceptibility, treatment, and 30-day infection-free survival. : Among 1725 patients with SI, 1433 were PHO and 292 were HCT patients. The cumulative incidence of SI was 12.7% in PHO and 14.3% in HCT patients ( = 0.008). The 30-day survival rate was significantly higher in PHO compared to HCT patients (98.4% vs. 93.2%, < 0.001). Most deaths were caused by , , and , predominantly involving methicillin-resistant coagulase-negative . Multivariate Cox regression identified undergoing HCT (HR = 3.0, 95% CI: 1.6-5.6, < 0.001) and treatment of infection > 10 days (HR = 2.0, 95% CI: 1.1-3.6, = 0.019) as independent risk factors for mortality. : Staphylococcal infections pose a significant challenge in paediatric oncology and transplant populations. Optimising prevention, diagnostics, and antimicrobial therapy is crucial for improving outcomes in these high-risk groups.
葡萄球菌属是患有恶性肿瘤或接受造血细胞移植（HCT）的儿童中最常见的革兰氏阳性菌，会导致显著的发病率和死亡率。本研究旨在评估波兰12年间儿科血液肿瘤学（PHO）和HCT患者葡萄球菌感染（SI）的流行病学、危险因素、治疗策略及结局。：在波兰17个儿科肿瘤中心开展了一项回顾性多中心研究。分析了2012年至2023年间确诊为SI的18岁以下恶性肿瘤患者或HCT后患者的临床和微生物学数据。评估的变量包括人口统计学、基础疾病、感染类型和来源、抗菌药物敏感性、治疗情况以及30天无感染生存率。：在1725例SI患者中，1433例为PHO患者，292例为HCT患者。PHO患者SI的累积发病率为12.7%，HCT患者为14.3%（P = 0.008）。PHO患者的30天生存率显著高于HCT患者（98.4%对93.2%，P < 0.001）。大多数死亡由金黄色葡萄球菌、表皮葡萄球菌和溶血葡萄球菌引起，主要涉及耐甲氧西林凝固酶阴性葡萄球菌。多变量Cox回归分析确定接受HCT（HR = 3.0，95%CI：1.6 - 5.6，P < 0.001）和感染治疗时间>10天（HR = 2.0，95%CI：1.1 - 3.6，P = 0.019）是死亡的独立危险因素。：葡萄球菌感染在儿科肿瘤和移植人群中构成重大挑战。优化预防、诊断和抗菌治疗对于改善这些高危人群的结局至关重要。
