Çakır Murat, Aksel İşbilen Ayşe, Eyüpoğlu İlker, Sağ Elif, Örem Asım, Mazlum Şen Tuğba, Kaklıkkaya Neşe, Kaya Gülay
Department of Pediatric Gastroenterology, Karadeniz Technical University School of Medicine, Trabzon, Turkey.
Turk J Gastroenterol. 2017 Sep;28(5):377-383. doi: 10.5152/tjg.2017.17084. Epub 2017 Aug 9.
BACKGROUND/AIMS: We aimed to analyze the efficiency of a novel treatment approach, long-term synbiotic supplementation, in addition to lifestyle changes in children with non-alcoholic fatty liver disease (NAFLD).
The study included children with NAFLD (n=28) and a healthy control group (n=30). Children with NAFLD were given 1 capsule/day of synbiotics. Anthropometric parameters; biochemical analysis, including ethanol, tumor necrosis factor-α (TNF-α), total oxidant status (TOS) and anti-oxidant status (TAS), zonulin, and fecal calprotectin; and ultrasonographic examination were performed at baseline and 4 months later.
The grade of fatty liver was decreased (≥1 grade) in 19 of the 28 patients (67.8%) after synbiotic supplementation. Total cholesterol, low-density lipoprotein (LDL) levels, TNF-α, C-reactive protein (CRP), and ethanol were significantly decreased, and TAS levels were significantly increased at the end of treatment (p<0.05 for all). We found that the median decrease in CRP (-0.16 vs. -0.03 mg/dL, p=0.003) and LDL levels (-17 vs. -3 mg/dL, p=0.019) were higher in patients who responded to the supplementation.
Synbiotic supplementation in addition to lifestyle changes is effective in children with NAFLD.
背景/目的：我们旨在分析一种新的治疗方法，即长期补充合生元，联合生活方式改变，对非酒精性脂肪性肝病（NAFLD）儿童的疗效。
该研究纳入了患有NAFLD的儿童（n = 28）和一个健康对照组（n = 30）。患有NAFLD的儿童每天服用1粒合生元胶囊。在基线和4个月后进行人体测量参数、生化分析（包括乙醇、肿瘤坏死因子-α（TNF-α）、总氧化状态（TOS）和抗氧化状态（TAS）、zonulin和粪便钙卫蛋白）以及超声检查。
补充合生元后，28例患者中有19例（67.8%）的脂肪肝等级降低（≥1级）。治疗结束时，总胆固醇、低密度脂蛋白（LDL）水平、TNF-α、C反应蛋白（CRP）和乙醇显著降低，TAS水平显著升高（所有p<0.05）。我们发现，对补充治疗有反应的患者中，CRP（-0.16 vs. -0.03 mg/dL，p = 0.003）和LDL水平（-17 vs. -3 mg/dL，p = 0.019）的中位数下降幅度更大。
除生活方式改变外，补充合生元对NAFLD儿童有效。
