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三种β-内酰胺分解代谢土壤菌的基因组序列草图

Draft Genome Sequences of Three β-Lactam-Catabolizing Soil .

作者信息

Crofts Terence S, Wang Bin, Spivak Aaron, Gianoulis Tara A, Forsberg Kevin J, Gibson Molly K, Johnsky Lauren A, Broomall Stacey M, Rosenzweig C Nicole, Skowronski Evan W, Gibbons Henry S, Sommer Morten O A, Dantas Gautam

机构信息

Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA

Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, USA.

出版信息

Genome Announc. 2017 Aug 10;5(32):e00653-17. doi: 10.1128/genomeA.00653-17.

Abstract

Most antibiotics are derived from the soil, but their catabolism there, which is necessary to close the antibiotic carbon cycle, remains uncharacterized. We report the first draft genome sequences of soil identified for subsisting solely on β-lactams as their carbon sources. The genomes encode multiple β-lactamases, although their antibiotic catabolic pathways remain enigmatic.

摘要

大多数抗生素来源于土壤,但其在土壤中的分解代谢(这是闭合抗生素碳循环所必需的)仍未得到充分研究。我们报告了首个仅以β-内酰胺类抗生素作为碳源的土壤微生物的基因组草图序列。这些基因组编码多种β-内酰胺酶,尽管它们的抗生素分解代谢途径仍不明确。

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Shared strategies for β-lactam catabolism in the soil microbiome.土壤微生物组中β-内酰胺代谢的共有策略。
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本文引用的文献

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Bacteria subsisting on antibiotics.依赖抗生素生存的细菌。
Science. 2008 Apr 4;320(5872):100-3. doi: 10.1126/science.1155157.
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Decomposition of streptomycin.链霉素的分解
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