Podgornaia E K, Galkina O V, Il'iuchenok R Iu, Poliakov O V
Institute of Inorganic Chemistry, Siberian Branch, Academy of Sciences, Novosibirsk, Russia.
Eksp Klin Farmakol. 1998 Jul-Aug;61(4):10-1.
The work discusses the neurochemical correlates of rat brain dopamin-synaptic activity after injection of 0.5 mg/kg rudotel (medazepam) as compared with intact animals. The parameters of functioning of D2-receptors in [3H]-dopamine binding, the content of catecholamines and their metabolites (high-performance liquid chromatography with electrochemical detection) were studied in the dopaminergic system in different brain areas (the striatum, frontal cortex, amygdala, hippocampus, hypothalamus, and accumbence).
该研究探讨了与未注射药物的正常动物相比，注射0.5mg/kg鲁多替尔（美达唑仑）后大鼠脑多巴胺突触活动的神经化学相关性。通过[3H] - 多巴胺结合研究D2受体的功能参数，利用高效液相色谱 - 电化学检测法研究了不同脑区（纹状体、额叶皮质、杏仁核、海马体、下丘脑和伏隔核）多巴胺能系统中儿茶酚胺及其代谢产物的含量。
