烟草、非法药物使用与 HIV 感染者心血管疾病风险。

Tobacco, illicit drugs use and risk of cardiovascular disease in patients living with HIV.

机构信息

Department of Cardiology, University Hospital Álvaro Cunqueiro, Vigo, Spain.

出版信息

Curr Opin HIV AIDS. 2017 Nov;12(6):523-527. doi: 10.1097/COH.0000000000000407.

Abstract

PURPOSE OF REVIEW

There is a strong link between HIV, smoking and illicit drugs. This association could be clinically relevant as it may potentiate the risk of cardiovascular diseases (CVD). The purpose of this review is to bring readers up to date on issues concerning the cardiovascular risk associated with tobacco and illicit drugs in patients living with HIV (PLHIV), examining the studies related to this topic published in the last year.

RECENT FINDINGS

There is a strong association between smoking and atherosclerotic disease in PLHIV, reducing life expectancy secondary to CVD by up to 6 years. Illicit drugs were associated with increased risk of atherosclerotic problems but to a lesser extent than smoking. A significant association of drugs such as cocaine with subclinical coronary atherosclerosis been demonstrated. The relation of marijuana, heroin and amphetamines with atherosclerosis generates more controversy. However, those drugs are associated with cardiovascular morbidity, independently of smoking and other traditional risk factors.

SUMMARY

Tobacco and illicit drugs are linked to CVD in HIV patients. This leads to the need to create special programs to address the addiction to smoking and illicit drugs, in order to mitigate their consequences and reduce cardiovascular risk.

摘要

目的综述

HIV、吸烟和非法药物之间存在着很强的关联。这种关联可能具有临床意义,因为它可能会增加心血管疾病(CVD)的风险。本文的目的是使读者了解与 HIV 感染者(PLHIV)中与烟草和非法药物相关的心血管风险相关的最新问题,同时探讨了过去一年中发表的相关研究。

最近的发现

在 PLHIV 中,吸烟与动脉粥样硬化疾病之间存在很强的关联,吸烟导致 CVD 使预期寿命缩短了长达 6 年。非法药物与动脉粥样硬化问题的风险增加有关,但程度低于吸烟。可卡因等药物与亚临床冠状动脉粥样硬化之间存在显著关联。大麻、海洛因和安非他命与动脉粥样硬化的关系存在更多争议。然而,这些药物与心血管发病率有关,与吸烟和其他传统危险因素无关。

总结

吸烟和非法药物与 HIV 患者的 CVD 有关。这就需要制定专门的方案来解决吸烟和非法药物成瘾问题,以减轻其后果并降低心血管风险。

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