Braund W J, Naylor B A, Williamson D H, Buley I D, Clark A, Chapel H M, Turner R C
Lancet. 1987 Jan 31;1(8527):237-40. doi: 10.1016/s0140-6736(87)90063-8.
A 76-year-old man with fasting hypoglycaemia had impaired in-vitro binding of insulin to erythrocyte receptors. The immunoglobulin fraction of his plasma inhibited binding of insulin to normal donor erythrocytes in vitro. Autoantibodies may have stimulated the insulin receptor and produced hypoglycaemia. Hodgkin's disease developed and may have induced the autoimmunity. The hypoglycaemia did not respond to plasmapheresis or azathioprine alone, but it remitted after the addition of prednisolone, and the erythrocyte receptor binding of insulin became normal.
一名76岁患有空腹低血糖的男性，其胰岛素与红细胞受体的体外结合受损。他血浆中的免疫球蛋白部分在体外可抑制胰岛素与正常供体红细胞的结合。自身抗体可能刺激了胰岛素受体并导致低血糖。患者后来患上了霍奇金病，可能诱发了自身免疫。单独进行血浆置换或使用硫唑嘌呤对低血糖均无反应，但加用泼尼松龙后低血糖症状缓解，且胰岛素与红细胞受体的结合恢复正常。
