来自重症监护病房（ICU）定植患者的艰难梭菌分离株的药敏试验显示，对ST-37（RT 017）分离株需予以警惕。
Antimicrobial susceptibility of Clostridium difficile isolates from ICU colonized patients revealed alert to ST-37 (RT 017) isolates.
作者信息
Yang Jingyu, Zhang Xiaoxia, Liu Xiaohua, Cai Lin, Feng Ping, Wang Xiaohui, Zong Zhiyong
机构信息
Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China; Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China.
Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China; Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China.
出版信息
Diagn Microbiol Infect Dis. 2017 Oct;89(2):161-163. doi: 10.1016/j.diagmicrobio.2017.06.021. Epub 2017 Jul 1.
Seventy Clostridium difficile isolates from ICU colonized patients were tested for antimicrobial susceptibility and screened for resistance determinants. We found that multilocus sequence type 37 (ribotype 017) toxin A-negative/B-positive isolates were more likely resistant to moxifloxacin than toxin A-positive/B-positive isolates (41.7% versus 9.3%) with major variations in both GyrA (Thr82Ile) and GyrB (Ser366Ala), suggesting that the use of quinolone should be more strictly regulated.
对70株来自重症监护病房（ICU）定植患者的艰难梭菌分离株进行了药敏试验，并筛选了耐药决定因素。我们发现，多位点序列类型37（核糖体分型017）毒素A阴性/毒素B阳性分离株比毒素A阳性/毒素B阳性分离株对莫西沙星耐药的可能性更高（41.7%对9.3%），同时gyrA（第82位苏氨酸突变为异亮氨酸）和gyrB（第366位丝氨酸突变为丙氨酸）均有主要变异，这表明喹诺酮类药物的使用应受到更严格的监管。
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