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Tumour cell-derived WNT5B modulates in vitro lymphangiogenesis via induction of partial endothelial-mesenchymal transition of lymphatic endothelial cells.肿瘤细胞衍生的WNT5B通过诱导淋巴管内皮细胞发生部分内皮-间充质转化来调节体外淋巴管生成。
Oncogene. 2017 Mar;36(11):1503-1515. doi: 10.1038/onc.2016.317. Epub 2016 Sep 5.
3
Methylenetetrahydrofolate dehydrogenase 2 overexpression is associated with tumor aggressiveness and poor prognosis in hepatocellular carcinoma.亚甲基四氢叶酸脱氢酶2过表达与肝细胞癌的肿瘤侵袭性及不良预后相关。
Dig Liver Dis. 2016 Aug;48(8):953-60. doi: 10.1016/j.dld.2016.04.015. Epub 2016 May 16.
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Metastasis as an evolutionary process.转移作为一个进化过程。
Science. 2016 Apr 8;352(6282):169-75. doi: 10.1126/science.aaf2784.
5
Overexpression of WNT5B promotes COLO 205 cell migration and invasion through the JNK signaling pathway.WNT5B的过表达通过JNK信号通路促进COLO 205细胞的迁移和侵袭。
Oncol Rep. 2016 Jul;36(1):23-30. doi: 10.3892/or.2016.4772. Epub 2016 Apr 27.
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National cancer incidence and mortality in China, 2012.2012年中国国家癌症发病率与死亡率
Chin J Cancer Res. 2016 Feb;28(1):1-11. doi: 10.3978/j.issn.1000-9604.2016.02.08.
7
The Wnt signaling pathway in cancer.癌症中的Wnt信号通路。
Crit Rev Oncol Hematol. 2016 Mar;99:141-9. doi: 10.1016/j.critrevonc.2015.12.005. Epub 2015 Dec 24.
8
A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis.非经典卷曲蛋白 2 信号通路调控上皮间质转化和转移。
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9
UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma.UHRF1 过表达导致 DNA 低甲基化和肝细胞癌。
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10
Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer.代谢酶表达凸显了MTHFD2和线粒体叶酸途径在癌症中的关键作用。
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[Wnt5b在乙型肝炎病毒相关肝细胞癌患者中的表达及其临床意义]

[Expression of Wnt5b in patients with HBV-related hepatocellular carcinoma and its clinical significance].

作者信息

Xiang Le-Yang, Ou Huo-Hui, Chen Zhan-Jun, Fang Ying-Hao, Huang Yu, Li Xiang-Hong, Yang Ding-Hua

机构信息

Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. E-mail:

出版信息

Nan Fang Yi Ke Da Xue Xue Bao. 2017 Aug 20;37(8):1071-1077. doi: 10.3969/j.issn.1673-4254.2017.08.12.

DOI:10.3969/j.issn.1673-4254.2017.08.12
PMID:28801288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6765743/
Abstract

OBJECTIVE

To investigate the expression of Wnt5b in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) tissues and its correlation with the clinicopathological parameters.

METHODS

Quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemical staining were employed to measure Wnt5b mRNA and protein expressions in two groups of HBV-related HCC patients (100 cases in each) selected from a cohort of 289 cases with HBV-related HCC using simple random sampling method. The correlation of Wnt5b expression with the clinicopathological parameters and the prognosis of HCC patients was analyzed.

RESULTS

Wnt5b mRNA expression was significantly higher in HCC tissues than that of adjacent noncancerous tissues in 65.0% (65/100) of the cases, and the positivity rate of Wnt5b protein was significantly higher in HCC tissues than that of adjacent noncancerous tissues (58.0% vs 22.0%, P<0.05). Wnt5b expression was significantly correlated with the tumor size (P<0.05), tumor number (P<0.01, only at the protein level), tumor differentiation (P<0.01, only at the protein level), TNM stage (P<0.05), BCLC stage (P<0.05), metastasis (P<0.05) and recurrence (P<0.01). The patients with up-regulated Wnt5b mRNA and protein had a shorter relapse-free survival (P<0.01).

CONCLUSION

s Up-regulated Wnt5b might contribute to the progression of HBV-related HCC and predicts a poor prognosis.

摘要

目的

探讨Wnt5b在乙型肝炎病毒（HBV）相关肝细胞癌（HCC）组织中的表达及其与临床病理参数的相关性。

方法

采用简单随机抽样法，从289例HBV相关HCC患者队列中选取两组HBV相关HCC患者（每组100例），运用定量实时聚合酶链反应（qRT-PCR）和免疫组织化学染色检测Wnt5b mRNA和蛋白表达。分析Wnt5b表达与临床病理参数及HCC患者预后的相关性。

结果

65.0%（65/100）的病例中，HCC组织中Wnt5b mRNA表达显著高于癌旁非癌组织，HCC组织中Wnt5b蛋白阳性率显著高于癌旁非癌组织（58.0%对22.0%，P<0.05）。Wnt5b表达与肿瘤大小（P<0.05）、肿瘤数目（P<0.01，仅在蛋白水平）、肿瘤分化（P<0.01，仅在蛋白水平）、TNM分期（P<0.05）、BCLC分期（P<0.05）、转移（P<0.05）和复发（P<0.01）显著相关。Wnt5b mRNA和蛋白上调的患者无复发生存期较短（P<0.01）。

结论

Wnt5b上调可能促进HBV相关HCC的进展并预示预后不良。