转录-复制冲突：方向很重要。
Transcription-Replication Conflicts: Orientation Matters.
机构信息
Institute of Human Genetics, CNRS UMR9002 and University of Montpellier, Equipe Labéllisée Ligue Contre le Cancer, 34090 Montpellier, France.
Institute of Human Genetics, CNRS UMR9002 and University of Montpellier, Equipe Labéllisée Ligue Contre le Cancer, 34090 Montpellier, France.
出版信息
Cell. 2017 Aug 10;170(4):603-604. doi: 10.1016/j.cell.2017.07.040.
Interference between DNA replication and transcription represents a major source of genomic instability. In this issue of Cell, Lang et al. and Hamperl et al. show that head-on collisions, but not codirectional collisions, impede fork progression in bacteria and in human cells by promoting the formation of RNA-DNA hybrids known as R-loops.
DNA 复制和转录之间的干扰是基因组不稳定的主要来源。在本期《细胞》杂志上，Lang 等人和 Hamperl 等人表明，在细菌和人类细胞中，只有头对头碰撞而非共方向碰撞会阻碍叉的前进，其原因是促进了 RNA-DNA 杂交体（称为 R 环）的形成。
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