Department of Applied Chemistry, University of Johannesburg, Johannesburg, South Africa.
Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran; Young Researchers and Elites Club, Science and Research Branch, Islamic Azad University, Tehran, Iran.
J Photochem Photobiol B. 2017 Sep;174:235-242. doi: 10.1016/j.jphotobiol.2017.08.006. Epub 2017 Aug 6.
In the present studies, modified NiO nanoparticles and MnO/NiO nanocomposites with guanidine were synthesized by anchoring method for carriers of anticancer drug "Caffeic acid phenethyl ester". The prepared nanocomposites were characterized by using Scanning Electron Microscopy, Raman and Fourier transform infrared spectroscopy, X-ray diffraction, Vibrating sample magnetometer. The results from XRD indicated that the crystalline size of NiO nanoparticles and MnO/NiO nanocomposites are 12 and 15nm, respectively. Saturation magnetization (Ms) for NiO NPs and MnO/NiO nanocomposites was to be 0.60, and 0.68emu/g indicating that these are superparamagnetic and ferromagnetic properties in nature. The prepared nanocomposites were evaluated as catalyst for degradation of antibiotics in photocatalysis process. Particularly, the MnO/NiO composite demonstrated the higher degradation rate (89.55%) of tetracycline antibiotic under UV light irradiation than the NiO (67.80%). Drug load on and release from nanopowders was investigated by using UV-Vis spectroscopy method. Time of drug loading was 100min and the drug release in 1-10h with 20-80% drug release were found, and then, it's applicable to in-vivo drug delivery. Therefore, the NiO nanoparticles and MnO/NiO nanocomposites are promising for targeted Caffeic acid phenethyl ester anticancer drug delivery applications. The anticancer drug loaded on guanidine-NiO and guanidine-MnO/NiO in high concentration has an antioxidant property.
在本研究中，通过锚定法合成了修饰的 NiO 纳米粒子和 MnO/NiO 纳米复合材料，作为抗癌药物“咖啡酸苯乙酯”的载体。通过扫描电子显微镜、拉曼和傅里叶变换红外光谱、X 射线衍射、振动样品磁强计对制备的纳米复合材料进行了表征。XRD 结果表明，NiO 纳米粒子和 MnO/NiO 纳米复合材料的结晶尺寸分别为 12nm 和 15nm。NiO NPs 和 MnO/NiO 纳米复合材料的饱和磁化强度（Ms）分别为 0.60 和 0.68emu/g，表明它们具有超顺磁性和铁磁性。制备的纳米复合材料被评估为光催化过程中抗生素降解的催化剂。特别是，MnO/NiO 复合材料在紫外光照射下对四环素抗生素的降解率（89.55%）高于 NiO（67.80%）。通过紫外-可见光谱法研究了纳米粉末的载药和释药性能。载药时间为 100min，在 1-10h 内释放 20-80%的药物，然后适用于体内药物输送。因此，NiO 纳米粒子和 MnO/NiO 纳米复合材料有望用于靶向咖啡酸苯乙酯抗癌药物输送应用。高浓度负载在胍-NiO 和胍-MnO/NiO 上的抗癌药物具有抗氧化性能。
