Lievens Y, De Schutter H, Stellamans K, Rosskamp M, Van Eycken L
Radiation Oncology Department, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium.
Belgian Cancer Registry, Koningsstraat/Rue Royale 215 Box 7, 1210 Brussels, Belgium.
Eur J Cancer. 2017 Oct;84:102-113. doi: 10.1016/j.ejca.2017.07.011. Epub 2017 Aug 9.
Underutilisation of radiotherapy has been observed worldwide. To evaluate the current situation in Belgium, optimal utilisation proportions (OUPs) adopted from the European SocieTy for Radiotherapy and Oncology - Health Economics in Radiation Oncology (ESTRO-HERO) project were compared to actual utilisation proportions (AUPs) and with radiotherapy advised during the multidisciplinary cancer team (MDT) meetings. In addition, the impact of independent variables was analysed.
AUPs and advised radiotherapy were calculated overall and by cancer type for 110,810 unique cancer diagnoses in 2009-2010. Radiotherapy utilisation was derived from reimbursement data and distinguished between palliative and curative intent external beam radiotherapy (EBRT) and/or brachytherapy (BT). Sensitivity analyses regarding the influence of the follow-up period, the survival length and patient's age were performed. Advised radiotherapy was calculated based on broad treatment categories as reported at MDT meetings.
The overall AUP of 37% (39% including BT) was lower than the OUP of 53%, but in line with advised radiotherapy (35%). Large variations by tumour type were observed: in some tumours (e.g. lung and prostate cancer) AUP was considerably lower than OUP, whereas in others there was reasonable concordance (e.g. breast and rectal cancer). Overall, 84% of treatments started within 9 months following diagnosis. Survival time influenced AUP in a cancer type-dependent way. Elderly patients received less radiotherapy.
Although the actually delivered radiotherapy in Belgium aligns well to MDT advices, it is lower than the evidence-based optimum. Further analysis of potential barriers is needed for radiotherapy forecasting and planning, and in order to promote adequate access to radiotherapy.
全球范围内均观察到放射治疗未得到充分利用的情况。为评估比利时的现状,将欧洲放射治疗与肿瘤学会-放射肿瘤学卫生经济学(ESTRO-HERO)项目采用的最佳利用比例(OUP)与实际利用比例(AUP)以及多学科癌症团队(MDT)会议期间建议的放射治疗进行了比较。此外,还分析了自变量的影响。
计算了2009 - 2010年110,810例独特癌症诊断的总体AUP以及按癌症类型划分的AUP和建议的放射治疗。放射治疗利用率来自报销数据,并区分了姑息性和根治性外照射放疗(EBRT)和/或近距离放疗(BT)。进行了关于随访期、生存时长和患者年龄影响的敏感性分析。建议的放射治疗是根据MDT会议报告的广泛治疗类别计算得出的。
总体AUP为37%(包括BT为39%),低于OUP的53%,但与建议的放射治疗(35%)相符。观察到不同肿瘤类型存在较大差异:在某些肿瘤(如肺癌和前列腺癌)中,AUP远低于OUP,而在其他肿瘤中则有合理的一致性(如乳腺癌和直肠癌)。总体而言,84%的治疗在诊断后9个月内开始。生存时间以癌症类型依赖的方式影响AUP。老年患者接受的放射治疗较少。
尽管比利时实际实施的放射治疗与MDT的建议契合度良好,但仍低于基于证据的最佳水平。为了进行放射治疗预测和规划,以及促进充分获得放射治疗,需要进一步分析潜在障碍。