Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles and Department of Biological Chemistry, David Geffen School of Medicine, Los Angeles, California
Physiol Genomics. 2017 Sep 1;49(9):491-495. doi: 10.1152/physiolgenomics.00049.2017. Epub 2017 Aug 11.
Emerging technologies for the analysis of genome-wide information in single cells have the potential to transform many fields of biology, including our understanding of cell states, the response of cells to external stimuli, mosaicism, and intratumor heterogeneity. At Experimental Biology 2017 in Chicago, hosted a symposium in which five leaders in the field of single cell genomics presented their recent research. The speakers discussed emerging methodologies in single cell analysis and critical issues for the analysis of single cell data. Also discussed were applications of single cell genomics to understanding the different types of cells within an organism or tissue and the basis for cell-to-cell variability in response to stimuli.
单细胞全基因组信息分析的新兴技术有可能改变许多生物学领域，包括我们对细胞状态、细胞对外界刺激的反应、嵌合体和肿瘤内异质性的理解。在芝加哥举行的 2017 年实验生物学会议上，[主办方]主办了一个研讨会，该领域的五位领导者在会上展示了他们最近的研究成果。演讲者讨论了单细胞分析中的新兴方法以及单细胞数据分析中的关键问题。他们还讨论了单细胞基因组学在理解生物体内或组织内不同类型细胞以及细胞对刺激反应的细胞间变异性的基础方面的应用。
