Kayseri Training and Research Hospital, Department of Emergency Medicine, Kayseri, Turkey.
Erciyes University, Faculty of Medicine, Department of Medical Biology, Kayseri, Turkey.
Am J Emerg Med. 2018 Feb;36(2):266-270. doi: 10.1016/j.ajem.2017.08.008. Epub 2017 Aug 7.
Endothelial nitric oxide synthase gene polymorphisms play a role in some pathophysiological processes. In this study, the possible effects of endothelial nitric oxide synthase gene polymorphisms on ureteral stone disease in patients who were admitted to the emergency department with severe pain due to renal colic are examined.
The study groups were designed as controls and patients. The control group was formed from the healthy volunteers who applied to the blood center next to the emergency service. The patient group comprised patients who were diagnosed with ureteral stone disease with severe pain. All of the genetic studies were based on extracted peripheral blood samples using the necessary procedures from the Genome and Stem Cell Center at Erciyes University (GENKOK). The data were analyzed with SPSS (IBM, ver 20, United Sate).
The study group comprised 62 females and 138 males, and the control group comprised 64 females and 136 males. All of the stones that caused renal colic were found to be localized in the ureters and the ureterovesical junction. The genotypes of the intron 4 polymorphism were found to be as follows: 4a/4a in 10 people, 4b/4a in 115, and 4b/4b in 275 people. The GG genotype of the eNOS-G894T polymorphism was found in 108 patients in the study group and in117 of the healthy individuals. There was no statistically significant difference between the two groups regarding these data.
Although this study is the first in the literature to examine the relationship between renal colic and endothelial nitric oxide synthase gene polymorphisms, our study demonstrated that no relation was found.
内皮型一氧化氮合酶基因多态性在一些病理生理过程中发挥作用。本研究旨在探讨内皮型一氧化氮合酶基因多态性对因肾绞痛就诊于急诊科的输尿管结石患者的影响。
研究组设计为对照组和患者组。对照组由就诊于急诊旁采血中心的健康志愿者组成。患者组由因输尿管结石伴严重疼痛而诊断为输尿管结石的患者组成。所有基因研究均基于从埃尔吉耶斯大学（GENKOK）基因组和干细胞中心提取的外周血样本，并采用必要的程序进行。使用 IBM SPSS（版本 20，美国）对数据进行分析。
研究组包括 62 名女性和 138 名男性，对照组包括 64 名女性和 136 名男性。所有引起肾绞痛的结石均位于输尿管和输尿管-膀胱交界处。第 4 内含子多态性的基因型为：4a/4a 为 10 人，4b/4a 为 115 人，4b/4b 为 275 人。eNOS-G894T 多态性的 GG 基因型在研究组中 108 例患者和对照组中 117 例健康个体中发现。两组间这些数据无统计学差异。
尽管本研究首次在文献中探讨了肾绞痛与内皮型一氧化氮合酶基因多态性的关系，但我们的研究表明两者之间无相关性。
