Nicula C, Nicula D, Pop R N
Cluj-Napoca University Ophthalmology Clinic, Cluj County Hospital, No. 3-5, Clinicilor Street, 400006 Cluj-Napoca, Romania; Iuliu Hațieganu University of Medicine and Pharmacy, Faculty of Medicine, No. 4, Louis Pasteur Street, 400349 Cluj-Napoca, Romania; OCULENS Ophthalmology Private Clinic, No. 7, Nicolae Pascaly Street, 400431 Cluj-Napoca, Romania.
OCULENS Ophthalmology Private Clinic, No. 7, Nicolae Pascaly Street, 400431 Cluj-Napoca, Romania.
J Fr Ophtalmol. 2017 Sep;40(7):535-541. doi: 10.1016/j.jfo.2017.03.003. Epub 2017 Aug 10.
Long-term evaluation of functional results based on visual acuity, keratometry, spherical equivalent and refractive cylinder in patients with progressive keratoconus treated with corneal collagen cross-linking (CXL).
We studied a group of 114 eyes of 91 consecutive patients treated from 2006 to 2009 by "Epi-off type" CXL. In the preoperative period, all patients had a complete ophthalmologic examination. The inclusion criteria were: patients aged 15 to 54years, with various stages of keratoconus, with a corneal thickness of at least 400μm at the thinnest point. The exclusion criteria were: patients with a corneal thickness of less than 400μm at the thinnest point, with Vogt's striae or herpetic keratitis, dry eye syndrome or aphakia. The patients were then followed at 1, 3 and 6months, and then every year between 1 and 7years postoperatively.
There was a decrease in the minimum K and maximum K, respectively 1.6 and 2.0, at 7years postop. (P<0.05). The cylinder decreased from -4.45 D to -3.50 D at 7 years postop (P<0.05). The spherical equivalent decreased by 1.66 D at 7 years (P<0.05). Uncorrected visual acuity increased from an average of 0.78 to 0.679 log MAR (P<0.05) at 7 years postop. The best-corrected visual acuity increased from a mean of 0.64 to 0.52 log Mar (P<0.05) at 7 years postop.
The results of CXL were stable at 7 years in all patients, consisting of reduction of keratometric values and refraction, and improvement in visual acuity.
基于视力、角膜曲率测量、等效球镜度和屈光柱镜度，对接受角膜交联术（CXL）治疗的圆锥角膜患者的功能结果进行长期评估。
我们研究了一组91例连续患者的114只眼，这些患者在2006年至2009年期间接受了“去上皮型”CXL治疗。术前，所有患者均进行了全面的眼科检查。纳入标准为：年龄在15至54岁之间，处于圆锥角膜的不同阶段，最薄点处角膜厚度至少为400μm。排除标准为：最薄点处角膜厚度小于400μm的患者、有Vogt条纹或疱疹性角膜炎的患者、干眼综合征患者或无晶状体患者。然后在术后1、3和6个月对患者进行随访，术后1至7年每年随访一次。
术后7年，最小角膜曲率（K）和最大角膜曲率分别下降了1.6和2.0（P<0.05）。术后7年，柱镜度从-4.45 D降至-3.50 D（P<0.05）。等效球镜度在术后7年下降了1.66 D（P<0.05）。术后7年，未矫正视力从平均0.78 log MAR提高到0.679 log MAR（P<0.05）。最佳矫正视力从平均0.64 log Mar提高到0.52 log Mar（P<0.05）。
CXL治疗7年时所有患者的结果均稳定，包括角膜曲率值和屈光的降低以及视力的改善。
