针对胃肠道营养感应机制治疗肥胖。

Targeting gastrointestinal nutrient sensing mechanisms to treat obesity.

机构信息

Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, W12 0NN, UK.

出版信息

Curr Opin Pharmacol. 2017 Dec;37:16-23. doi: 10.1016/j.coph.2017.07.005. Epub 2017 Aug 10.

DOI:10.1016/j.coph.2017.07.005

Abstract

Gut hormones have important roles in the regulation of appetite and glucose homeostasis. Understanding how macronutrient sensing in the gastrointestinal tract modulates gut hormone release may reveal novel pharmacological or dietary approaches to metabolic disease. In this short review we discuss the mechanisms by which the gut senses macronutrients and the products of macronutrient digestion, and their putative utility in treating obesity and related conditions.

摘要

肠道激素在调节食欲和葡萄糖稳态方面发挥着重要作用。了解胃肠道中宏量营养素的感知如何调节肠道激素的释放，可能揭示出治疗代谢性疾病的新的药理学或饮食方法。在这篇简短的综述中，我们讨论了肠道感知宏量营养素和宏量营养素消化产物的机制，以及它们在治疗肥胖症和相关疾病方面的潜在用途。