Department of Psychological and Brain Sciences, University of Massachusetts, Amherst, 135 Hicks Way, Amherst, MA 01003, United States.
Department of Pharmacology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, United States.
Front Neuroendocrinol. 2017 Oct;47:134-153. doi: 10.1016/j.yfrne.2017.08.002. Epub 2017 Aug 9.
Loss of ovarian function in women is associated with sleep disturbances and cognitive decline, which suggest a key role for estrogens and/or progestins in modulating these symptoms. The effects of ovarian hormones on sleep and cognitive processes have been studied in separate research fields that seldom intersect. However, sleep has a considerable impact on cognitive function. Given the tight connections between sleep and cognition, ovarian hormones may influence selective aspects of cognition indirectly, via the modulation of sleep. In support of this hypothesis, a growing body of evidence indicates that the development of sleep disorders following menopause contributes to accelerated cognitive decline and dementia in older women. This paper draws from both the animal and human literature to present an integrated view of the effects of ovarian hormones on sleep and cognition across the adult female lifespan.
女性卵巢功能的丧失与睡眠障碍和认知能力下降有关，这表明雌激素和/或孕激素在调节这些症状方面起着关键作用。卵巢激素对睡眠和认知过程的影响已在很少交叉的单独研究领域中进行了研究。然而，睡眠对认知功能有相当大的影响。鉴于睡眠和认知之间的紧密联系，卵巢激素可能会通过调节睡眠间接影响认知的某些特定方面。有越来越多的证据支持这一假说，即绝经后睡眠障碍的发展导致老年女性认知能力下降和痴呆的加速。本文综合了动物和人类文献，提出了一个关于卵巢激素对成年女性整个生命周期睡眠和认知的综合影响的观点。
