Philippi N, Noblet V, Duron E, Cretin B, Boully C, Wisniewski I, Seux M L, Martin-Hunyadi C, Chaussade E, Demuynck C, Kremer S, Lehéricy S, Gounot D, Armspach J P, Hanon O, Blanc F
Department of Neurology, University Hospital of Strasbourg, Neuropsychology Unit, Strasbourg, France.
University of Strasbourg, CNRS, ICube laboratory, FMTS, Strasbourg, France.
Alzheimers Res Ther. 2016 Jul 30;8(1):26. doi: 10.1186/s13195-016-0190-1.
The aim of this volumetric study was to explore the neuroanatomical correlates of the Free and Cued Selective Reminding Test (FCSRT) and the Delayed Matching-to-Sample-48 items (DMS-48), two tests widely used in France to assess verbal and visual anterograde memory. We wanted to determine to what extent the two tests rely on the medial temporal lobe, and could therefore be predictive of Alzheimer's disease, in which pathological changes typically start in this region.
We analysed data from a cohort of 138 patients with mild cognitive impairment participating in a longitudinal multicentre clinical research study. Verbal memory was assessed using the FCSRT and visual recognition memory was evaluated using the DMS-48. Performances on these two tests were correlated to local grey matter atrophy via structural MRI using voxel-based morphometry.
Our results confirm the existence of a positive correlation between the volume of the medial temporal lobe and the performance on the FCSRT, prominently on the left, and the performance on the DMS-48, on the right, for the whole group of patients (family-wise error, P < 0.05). Interestingly, this region remained implicated only in the subgroup of patients who had deficient scores on the cued recall of the FCSRT, whereas the free recall was associated with prefrontal aspects. For the DMS-48, it was only implicated for the group of patients whose performances declined between the immediate and delayed trial. Conversely, temporo-parietal cortices were implicated when no decline was observed. Within the medial temporal lobe, the parahippocampal gyrus was prominently involved for the FCSRT and the immediate trial of the DMS-48, whereas the hippocampus was solely involved for the delayed trial of the DMS-48.
The two tests are able to detect an amnestic profile of the medial temporal type, under the condition that the scores remain deficient after the cued recall of the FCSRT or decline on the delayed recognition trial of the DMS-48. Strategic retrieval as well as perceptual/attentional processes, supported by prefrontal and temporo-parietal cortices, were also found to have an impact on the performances. Finally, the implication of the hippocampus appears time dependent, triggered by a longer delay than the parahippocampus, rather than determined by the sense of recollection or the encoding strength associated with the memory trace.
本容积研究旨在探究自由与线索选择回忆测验（FCSRT）和延迟匹配样本48项测验（DMS - 48）的神经解剖学关联，这两项测验在法国被广泛用于评估言语和视觉顺行性记忆。我们想确定这两项测验在多大程度上依赖内侧颞叶，因此能否预测阿尔茨海默病，该病的病理变化通常始于该区域。
我们分析了138名轻度认知障碍患者的数据，这些患者参与了一项纵向多中心临床研究。使用FCSRT评估言语记忆，使用DMS - 48评估视觉识别记忆。通过基于体素的形态测量法，利用结构磁共振成像将这两项测验的表现与局部灰质萎缩相关联。
我们的结果证实，对于整个患者组，内侧颞叶体积与FCSRT的表现（主要在左侧）以及DMS - 48的表现（在右侧）之间存在正相关（家族性错误率，P < 0.05）。有趣的是，该区域仅在FCSRT线索回忆得分不足的患者亚组中起作用，而自由回忆与前额叶方面相关。对于DMS - 48，它仅在即时试验和延迟试验之间表现下降的患者组中起作用。相反，当未观察到下降时，颞顶叶皮质起作用。在内侧颞叶内，海马旁回在FCSRT和DMS - 48的即时试验中显著受累，而海马仅在DMS - 48的延迟试验中受累。
这两项测验能够检测到内侧颞叶类型的遗忘特征，条件是FCSRT线索回忆后得分仍不足或DMS - 48延迟识别试验中表现下降。前额叶和颞顶叶皮质支持的策略性检索以及感知/注意力过程也被发现对表现有影响。最后，海马的受累似乎与时间有关，由比海马旁回更长的延迟触发，而不是由与记忆痕迹相关的回忆感或编码强度决定。
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