Neurology, King's College Hospital, London, UK.
Neuroepidemiology. 2017;49(1-2):1-17. doi: 10.1159/000478702. Epub 2017 Aug 12.
Ethnic variations have been described in medical conditions, such as hypertension, diabetes, and multiple sclerosis. Whether ethnicity plays a role in Parkinson's disease (PD), particularly with regard to non-motor symptoms (NMS), remains unclear. Existing literature is diverse, controversial, and inadequately documented. This review aims to analyse and report the currently available literature on NMS, specifically in Asian PD patients.
We conducted a literature review using PubMed, searching for articles and currently available publications that reference and assess NMS in PD patients living in Asia using the validated NMS Questionnaire (NMS Quest) and NMS Scale (NMSS). In total, 24 articles were included: 12 using the NMS Quest and 12 using the NMSS. Symptoms of constipation, memory impairment, and nocturia were the most frequently self-reported symptoms (NMS Quest) in selected Asian populations, while symptoms within the domains sleep/fatigue, attention/memory, and mood/apathy were most prevalent when applying the health-professional completed NMSS. Key Messages: NMS are generally prevalent and highly burdensome within selected Asian PD populations living in countries included in this review. Our review suggests that NMS-driven phenotypic heterogeneity is present in Asian patients, and compared to Western PD populations there might be variations in assessed NMS.
在高血压、糖尿病和多发性硬化症等医学病症中，已经描述了种族差异。种族是否在帕金森病（PD）中起作用，特别是在非运动症状（NMS）方面，尚不清楚。现有文献存在多样性、争议性和记录不足的问题。本综述旨在分析和报告目前关于 NMS 的文献，特别是在亚洲 PD 患者中的研究。
我们使用 PubMed 进行了文献综述，检索了使用经过验证的 NMS 问卷（NMS Quest）和 NMS 量表（NMSS）评估亚洲 PD 患者 NMS 的文章和现有出版物。共纳入 24 篇文章：12 篇使用 NMS Quest，12 篇使用 NMSS。在选定的亚洲人群中，便秘、记忆力减退和夜尿症是最常自我报告的症状（NMS Quest），而在应用专业人员完成的 NMSS 时，睡眠/疲劳、注意力/记忆和情绪/淡漠等领域的症状最为普遍。
在本综述纳入的亚洲国家的 PD 患者中，NMS 通常普遍存在且负担沉重。我们的综述表明，亚洲患者中存在 NMS 驱动的表型异质性，与西方 PD 人群相比，评估的 NMS 可能存在差异。
