Ojo Oluwadamilola O, Wahab Kolawole W, Bello Abiodun H, Abubakar Sani A, Ekeh Bertha C, Otubogun Folajimi M, Iwuozo Emmanuel U, Farombi Temitope H, Adeniji Olaleye, Ojini Francis I, Imarhiagbe Frank A, Nyandaiti Yakub, Komolafe Morenikeji A, Fawale Michael B, Onwuegbuzie Gerald A, Zubair Yusuf, Williams Uduak E, Taiwo Funlola T, Oyakhire Shyngle I, Oshinaike Olajumoke O, Osemwegie Nosakhare, Osaigbovo Godwin O, Odiase Francis E, Odeniyi Olanike A, Obiabo Yahaya O, Obehighe Emmanuel E, Nwazor Ernest O, Nwani Paul O, Kehinde Abiodun J, Erameh Cyril O, Ekenze Oluchi S, Dike Franklin O, Balarabe Salisu A, Arigbodi Ohwotemu, Arabambi Babawale, Ani-Osheku Ifeyinwa, Ali Mohammed W, Akpekpe John E, Akinyemi Rufus O, Agulanna Uchechi, Agu Christian E, Agabi Osigwe P, Ademiluyi Babatunde A, Adebowale Akintunde A, Achoru Charles O, Abiodun Oladunni V, Rizig Mie, Okubadejo Njideka U
Neurology Unit, Department of Medicine, Faculty of Clinical Sciences College of Medicine, University of Lagos Lagos Nigeria.
Neurology Unit, Department of Medicine Lagos University Teaching Hospital Lagos Nigeria.
Mov Disord Clin Pract. 2021 Oct 6;8(8):1206-1215. doi: 10.1002/mdc3.13346. eCollection 2021 Nov.
Data on non-motor symptoms (NMS) in black Africans with Parkinson's disease (PD) are sparse.
To describe the profile of NMS in the Nigeria PD Registry (NPDR) cohort and explore the relationship between NMS and PD motor phenotype.
We conducted a cross-sectional study of the frequency and burden of NMS, based on the non-motor symptoms scale (NMSS) and the Chaudhuri method respectively in our cohort. Baseline demographics, disease characteristics (Hoehn and Yahr stage, MDS-UPDRS total score and Part III motor score), motor phenotype (based on Stebbin et al's algorithm), and levodopa equivalent daily dose (LEDD) were documented.
Data are presented for 825 PD whose mean age at study was 63.7 ± 10.1 years, female sex-221 [26.8%] while median PD duration was 36 months. PD phenotypes included tremor-dominant 466 (56.5%), postural instability and gait disorder (PIGD) 259 (31.4%), and indeterminate 100 (12.1%). 82.6% were on treatment (median LEDD of 500 mg/24 hours). 804 (97.5%) endorsed at least 1 NMS. The median NMSS score was 26.0 while subscores for urinary and sexual function domains were significantly higher in males ( < 0.05). PIGD-PD had more frequent NMS and higher frequency of severe/very severe NMSS burden ( = 0.000 for both). Nocturia and fatigue were the most prevalent NMS overall and across motor subtypes. PIGD phenotype and total UPDRS scores were the independent determinants of NMSS scores ( = 0.000).
The profile and burden of NMS, and association with motor subtype in our black African cohort is largely similar to descriptions from other populations.
关于非洲黑人帕金森病（PD）患者非运动症状（NMS）的数据较为稀少。
描述尼日利亚帕金森病注册研究（NPDR）队列中的非运动症状特征，并探讨非运动症状与帕金森病运动表型之间的关系。
我们在队列中分别基于非运动症状量表（NMSS）和乔杜里方法对非运动症状的频率和负担进行了横断面研究。记录了基线人口统计学数据、疾病特征（霍恩和雅尔分期、MDS-UPDRS总分及第三部分运动评分）、运动表型（基于斯特宾等人的算法）以及左旋多巴等效日剂量（LEDD）。
呈现了825例帕金森病患者的数据，研究时的平均年龄为63.7±10.1岁，女性221例[26.8%]，帕金森病病程中位数为36个月。帕金森病表型包括震颤为主型466例（56.5%）、姿势不稳和步态障碍（PIGD）型259例（31.4%）以及不确定型100例（12.1%）。82.6%的患者正在接受治疗（LEDD中位数为500mg/24小时）。804例（97.5%）患者认可至少一种非运动症状。NMSS评分中位数为26.0，而男性在泌尿和性功能领域的子评分显著更高（P<0.05）。PIGD型帕金森病患者的非运动症状更频繁，且严重/非常严重NMSS负担的频率更高（两者P均=0.000）。夜尿症和疲劳是总体及各运动亚型中最常见的非运动症状。PIGD表型和UPDRS总分是NMSS评分的独立决定因素（P=0.000）。
我们这个非洲黑人队列中的非运动症状特征和负担，以及与运动亚型的关联在很大程度上与其他人群的描述相似。
