Sandqvist G, Wollmer P, Scheja A, Wildt M, Hesselstrand R
a Department of Clinical Sciences Lund, Section of Rheumatology , Lund University, Skåne University Hospital , Lund , Sweden.
b Department of Translational Medicine , Lund University , Lund , Sweden.
Scand J Rheumatol. 2018 May;47(3):206-209. doi: 10.1080/03009742.2017.1350745. Epub 2017 Aug 13.
To investigate Raynaud's phenomenon (RP) and its impact on daily life activities during 1 year of follow-up in early systemic sclerosis (SSc).
Fourteen SSc patients with a median disease duration of 2 years were enrolled in the study. Every 7 weeks the patients completed a 7 day diary documenting the frequency and duration of RP attacks, the activity causing the attack, and how they handled the attack. The patients also recorded in the diary daily self-assessments of the difficulties with RP, using a 0-10 ordinal scale according to the Raynaud's Condition Score.
Ninety-eight RP weekly diaries were analysed. The median number of RP attacks varied between six and nine per week, and the median score reflecting the difficulty associated with the attacks varied between 2.0 and 2.9. No difference was found in the number of attacks or the difficulties associated with them between winter, spring, and autumn. Fewer attacks and less difficulty were reported in August than in any of the other documented weeks (p < 0.05). In all diaries, all patients reported RP attacks associated with domestic activities. The use of heating devices varied during the follow-up. In February, all patients except one used such devices, while about half of the group used devices during the rest of the year.
Difficulties resulting from RP are present and disabling all year round, which underscore the importance of intense vasoactive therapy and non-pharmacological strategies throughout the year.
调查早期系统性硬化症（SSc）患者在1年随访期间的雷诺现象（RP）及其对日常生活活动的影响。
14例疾病持续时间中位数为2年的SSc患者纳入本研究。每7周，患者完成一份为期7天的日记，记录RP发作的频率和持续时间、引发发作的活动以及他们如何应对发作。患者还根据雷诺病情评分，使用0至10的序数量表在日记中记录每日对RP相关困难的自我评估。
分析了98份RP每周日记。RP发作的中位数为每周6至9次，反映发作相关困难的中位数评分在2.0至2.9之间。冬季、春季和秋季的发作次数或与之相关的困难没有差异。8月报告的发作次数和困难程度均低于其他任何记录周（p<0.05）。在所有日记中，所有患者均报告了与家务活动相关的RP发作。随访期间加热设备的使用情况有所不同。2月，除1名患者外，所有患者都使用了此类设备，而在一年中的其他时间，约一半患者使用了设备。
RP导致的困难全年存在且使人丧失能力，这突出了全年强化血管活性治疗和非药物策略的重要性。
