Mirault Tristan, Guillet Henri, Messas Emmanuel
Rare Vascular Diseases French National Reference Center, hôpital européen Georges-Pompidou, AP-HP, Paris Descartes University, Sorbonne Paris Cité, PARCC, Department of Vascular Medicine, Inserm U970, 75015 Paris, France.
Rare Vascular Diseases French National Reference Center, hôpital européen Georges-Pompidou, AP-HP, Paris Descartes University, Sorbonne Paris Cité, PARCC, Department of Vascular Medicine, Inserm U970, 75015 Paris, France.
Presse Med. 2017 Jul-Aug;46(7-8 Pt 2):e189-e196. doi: 10.1016/j.lpm.2017.07.002. Epub 2017 Aug 10.
Takayasu arteritis (TAK) is a vasculitis of the large arteries. The arterial wall, target of the immune reaction, is composed of vascular dendritic cells, endothelial cells, vascular smooth muscle cells and fibroblasts, which engage in an interaction with T cells and macrophages to, ultimately, cause luminal stenosis or aneurysmal wall damage of the vessel. A multitude of cytokines have been identified to increase in case of TAK and to be linked to disease activity. A better understanding of the physiopathological pathways and mechanisms involved, might enable a more tailored therapeutic approach in TAK.
高安动脉炎（TAK）是一种累及大动脉的血管炎。作为免疫反应靶点的动脉壁由血管树突状细胞、内皮细胞、血管平滑肌细胞和成纤维细胞组成，这些细胞与T细胞和巨噬细胞相互作用，最终导致血管腔狭窄或动脉瘤壁损伤。已确定多种细胞因子在TAK患者中升高，并与疾病活动相关。更好地了解其中涉及的生理病理途径和机制，可能有助于在TAK中采取更具针对性的治疗方法。
