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[神经介质系统在神经症及类神经症状态发病机制中作用的临床与实验研究]

[Clinical and experimental studies of the role of neuromediator systems in the pathogenesis of neurosis and neurosis-like states].

作者信息

Aĭrapetiants M G, D'iakova S D, Maslova A F

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1986;86(11):1698-703.

PMID:2880440
Abstract

Clinical studies revealed a significant increase in the peripheral blood levels of noradrenaline in patients with different forms of neurosis and neurosis-like states as compared to control subjects as well as heterogeneous or unidirectional but differently pronounced changes in blood levels of acetylcholine and adrenaline. Comparison of the clinical findings with the results of dynamic assays for peripheral levels of acetylcholine and catecholamine in dogs exposed to special psychogenic and physiogenic impacts has helped to form an understanding about some common mechanisms of the formation of neuroses and neurosis-like states. The authors emphasize the consistency of neuromediator shifts in the blood of patients and the possibility of using this parameter for the differential diagnosis of various forms of neurotic disturbances at the initial stage of the disease.

摘要

临床研究表明,与对照组相比,不同形式神经症和类神经症状态患者外周血中去甲肾上腺素水平显著升高,乙酰胆碱和肾上腺素水平则发生异质性或单向性但程度不同的变化。将临床研究结果与受到特殊心理和生理影响的犬类外周乙酰胆碱和儿茶酚胺水平动态检测结果进行比较,有助于形成对神经症和类神经症状态形成的一些共同机制的理解。作者强调患者血液中神经介质变化的一致性,以及在疾病初期利用该参数对各种形式的神经症性障碍进行鉴别诊断的可能性。

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