[Clinical and experimental studies of the role of neuromediator systems in the pathogenesis of neurosis and neurosis-like states].

Clinical studies revealed a significant increase in the peripheral blood levels of noradrenaline in patients with different forms of neurosis and neurosis-like states as compared to control subjects as well as heterogeneous or unidirectional but differently pronounced changes in blood levels of acetylcholine and adrenaline. Comparison of the clinical findings with the results of dynamic assays for peripheral levels of acetylcholine and catecholamine in dogs exposed to special psychogenic and physiogenic impacts has helped to form an understanding about some common mechanisms of the formation of neuroses and neurosis-like states. The authors emphasize the consistency of neuromediator shifts in the blood of patients and the possibility of using this parameter for the differential diagnosis of various forms of neurotic disturbances at the initial stage of the disease.