Mekhedova A Ia, Kozlovskaia M M, Neznamov G G, Nikuradze V O
Zh Vyssh Nerv Deiat Im I P Pavlova. 1985 Nov-Dec;35(6):1147-55.
In modelling of neuroses, successive stages of development of this pathology were observed in dogs. The first stage is characterized by circular disturbances of conditioned activity, vegetative shifts of compensatory character and intensification of individual characteristics of behaviour. At the second stage, parallel with sharp disturbances of conditioned reflexes and with vegetative dystonia, a distortion of emotional reactions was observed in dogs. It is essential that resumption of neurotization episodes in experiments on dogs with the second stage of disease promoted a development of depressive-like states. Diazepam corrected the behavioural and vegetative shifts at the first stage of neurosis. Non-typical antidepressants eliminated the manifestation of symptoms complex of the disease, especially at prolonged treatment.
在神经症建模中，在狗身上观察到了这种病理的连续发展阶段。第一阶段的特征是条件活动的循环紊乱、具有代偿性质的植物性变化以及行为个体特征的强化。在第二阶段，与条件反射的急剧紊乱和植物性肌张力障碍同时，在狗身上观察到了情绪反应的扭曲。重要的是，在患有疾病第二阶段的狗的实验中恢复神经化发作促进了抑郁样状态的发展。地西泮纠正了神经症第一阶段的行为和植物性变化。非典型抗抑郁药消除了疾病症状复合体的表现，尤其是在长期治疗时。
