Zheng Wenxian, Zhang Shuisheng, Zhang Shenfeng, Min Li, Wang Yihong, Xie Jian, Hou Yong, Tian Xiufang, Cheng Jian, Liu Kun, Xu Deguo, Yu Xinshuang, Liu Zhen, Lv Yajuan, Liang Ning, Zhang Jiandong, Liu Fengjun, Tian Yuan
Department of Oncology, Shanghai Jiaotong University Affiliated Sixth People Hospital, Shanghai 200233, P.R. China.
Department of Abdominal Surgical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China.
Biomed Rep. 2017 Aug;7(2):133-142. doi: 10.3892/br.2017.934. Epub 2017 Jun 28.
The aim of the present study was to evaluate the relationship between tumor necrosis factor-α (-α) and the development of gastric cancer, and to investigate whether it can be used as a biological marker for gastric cancer. In the current study, a new meta-analysis was performed to assess the association between -α gene polymorphisms and gastric cancer susceptibility. Subgroup analyses based on ethnicity, control population source and non-cardia cancers were also conducted. Summary odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model. polymorphisms indicated a significant relationship with gastric cancer risk among a normal population [GA/AA vs. GG; 1.17 (1.10-1.23)]. In analysis stratified by ethnicity, displayed an association with gastric cancer risk in eastern populations [GA/AA vs. GG: 1.24 (1.02-1.50)], but not in western populations [GA/AA vs. GG: 0.96 (0.79-1.18)]. The overall ORs (95% CIs) for TNF-α 857, and were 1.13 (1.04-1.24), 0.94 (0.85-1.05) and 0.89 (0.78-1.02), respectively, under dominant genetic model comparison. Among the above three SNPs, only was robustly associated with gastric cancer inclination, and this association remained consistently robust when limited to non-cardia gastric cancers [GA/AA vs. GG: 1.16 (1.03-1.31)]. and genotypes were potential risk factors of statistical significance in gastric cancer, and indicated to be significantly associated with gastric cancer risk only in eastern populations. and were not significantly associated with gastric cancer risk.
本研究的目的是评估肿瘤坏死因子-α（TNF-α）与胃癌发生之间的关系，并探讨其是否可作为胃癌的生物标志物。在本研究中，进行了一项新的荟萃分析，以评估TNF-α基因多态性与胃癌易感性之间的关联。还基于种族、对照人群来源和非贲门癌进行了亚组分析。使用随机效应模型计算了95%置信区间（CIs）的汇总比值比（ORs）。多态性表明在正常人群中与胃癌风险存在显著关系[GA/AA与GG相比；1.17（1.10 - 1.23）]。在按种族分层的分析中，在东方人群中显示与胃癌风险相关[GA/AA与GG相比：1.24（1.02 - 1.50）]，但在西方人群中不相关[GA/AA与GG相比：0.96（0.79 - 1.18）]。在显性遗传模型比较下，TNF-α 857、[此处可能有信息缺失]和[此处可能有信息缺失]的总体ORs（95% CIs）分别为1.13（1.04 - 1.24）、0.94（0.85 - 1.05）和0.89（0.78 - 1.02）。在上述三个单核苷酸多态性（SNPs）中，只有[此处可能有信息缺失]与胃癌倾向密切相关，并且当仅限于非贲门胃癌时，这种关联仍然始终显著[GA/AA与GG相比：1.16（1.03 - 1.31）]。[此处可能有信息缺失]和[此处可能有信息缺失]基因型是胃癌中具有统计学意义的潜在危险因素，并且[此处可能有信息缺失]仅在东方人群中显示与胃癌风险显著相关。[此处可能有信息缺失]和[此处可能有信息缺失]与胃癌风险无显著关联。
