Department of General Surgery, The Third Affiliated Hospital to Nantong University, Wuxi, China.
PLoS One. 2011;6(7):e22092. doi: 10.1371/journal.pone.0022092. Epub 2011 Jul 19.
Tumor necrosis factor-α (TNF-α) plays a very important role in the development and progress of cancer. Some TNF-α polymorphisms have been confirmed to increase cancer risks; however, the association between TNF-α-238 polymorphism and cancers remains controversial and ambiguous. The aim of this study is to explore a more precise estimation of its relationship with cancer using meta-analysis.
Electronic searches of several databases were conducted for all publications on the association between this variant and cancer through March 2011. Odds ratios (OR) with 95% confidence intervals (95% CI) were used to access the strength of this association in the random-effect model.
Thirty four studies with 34,679 cancer patients and 41,186 healthy controls were included. This meta-analysis showed no significant association between TNF-α-238 polymorphism and cancers (AA+GA vs GG: OR = 1.09, 95%CI = 0.88-1.34). In Caucasian and Asian subgroups, OR values (95% CI) were 1.14 (0.91-1.43) and 0.97 (0.58-1.61), respectively. In the subgroups of cancer type, no significant association was detected. The sensitivity analysis further strengthened the validity of these negative associations. No publication bias was observed in this study.
No significant association was found between the TNF-α-238 polymorphism and the risk for cancer.
肿瘤坏死因子-α（TNF-α）在癌症的发生和发展中起着非常重要的作用。一些 TNF-α 多态性已被证实会增加癌症风险；然而，TNF-α-238 多态性与癌症之间的关系仍然存在争议和模糊。本研究旨在通过荟萃分析探讨更精确地评估其与癌症之间关系的方法。
通过电子检索，对截至 2011 年 3 月所有关于该变异与癌症之间关联的研究进行了分析。使用随机效应模型，用比值比（OR）及其 95%置信区间（95%CI）来评估这种关联的强度。
共纳入 34 项研究，包括 34679 例癌症患者和 41186 例健康对照者。本荟萃分析显示，TNF-α-238 多态性与癌症之间无显著关联（AA+GA 与 GG：OR=1.09，95%CI=0.88-1.34）。在白人和亚洲亚组中，OR 值（95%CI）分别为 1.14（0.91-1.43）和 0.97（0.58-1.61）。在癌症类型亚组中，未发现显著相关性。敏感性分析进一步证实了这些阴性关联的有效性。本研究未发现发表偏倚。
TNF-α-238 多态性与癌症风险之间未发现显著相关性。
