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低剂量S-1治疗颊部鳞状细胞癌取得成功结果。

Successful Outcome of Low-Dose S-1 Used to Treat Buccal Squamous Cell Carcinoma.

作者信息

Yusa Kazuyuki, Yamanouchi Hideyuki, Sugano Ayako, Iino Mitsuyoshi

机构信息

Department of Dentistry, Oral and Maxillofacial, Plastic and Reconstructive Surgery, Yamagata University Faculty of Medicine, Yamagata, Japan.

Department of Dentistry and Oral Surgery, Shinjo Tokushukai Hospital, Yamagata, Japan.

出版信息

Case Rep Oncol Med. 2017;2017:4537631. doi: 10.1155/2017/4537631. Epub 2017 Jul 18.

DOI:10.1155/2017/4537631
PMID:28804664
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5540467/
Abstract

This case report describes an 86-year-old woman with dormant right buccal squamous cell carcinoma who was able to maintain a reasonable quality of life after being treated with oral low-dose S-1 (80 mg/day). The treatment regimen started in April 2014 and consisted of two weeks of S-1 followed by a one-week interval. The patient remains on this regimen while maintaining her quality of life and she has been under follow-up as an outpatient for 36 months. The outcomes for this patient indicated that low-dose S-1 is a valid anticancer therapy that may help maintain quality of life for some patients with incurable or dormant cancers.

摘要

本病例报告描述了一名86岁患有静止性右颊部鳞状细胞癌的女性,在接受口服低剂量S-1(80毫克/天)治疗后能够维持合理的生活质量。治疗方案于2014年4月开始,包括服用两周S-1,随后间隔一周。患者一直采用该方案,同时维持其生活质量,并且作为门诊患者接受了36个月的随访。该患者的治疗结果表明,低剂量S-1是一种有效的抗癌疗法,可能有助于一些患有无法治愈或静止性癌症的患者维持生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ade/5540467/b640d732ec82/CRIONM2017-4537631.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ade/5540467/5661d3f18897/CRIONM2017-4537631.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ade/5540467/b640d732ec82/CRIONM2017-4537631.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ade/5540467/5661d3f18897/CRIONM2017-4537631.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ade/5540467/b640d732ec82/CRIONM2017-4537631.002.jpg

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本文引用的文献

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Pharmacokinetics of metronomic chemotherapy: a neglected but crucial aspect.节拍化疗的药代动力学:一个被忽视但至关重要的方面。
Nat Rev Clin Oncol. 2016 Nov;13(11):659-673. doi: 10.1038/nrclinonc.2016.64. Epub 2016 May 17.
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S-1 monotherapy as second- or third-line chemotherapy for unresectable and recurrent esophageal squamous cell carcinoma.S-1 单药治疗作为不可切除和复发性食管鳞癌的二线或三线化疗。
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S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial.S-1联合顺铂与单用S-1作为晚期胃癌一线治疗的疗效比较(SPIRITS试验):一项III期试验
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Eur J Cancer. 2004 Sep;40(14):2071-6. doi: 10.1016/j.ejca.2004.05.019.
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