皮肤和肠道微生物群在银屑病中的作用
The Role of the Skin and Gut Microbiome in Psoriatic Disease.
作者信息
Yan Di, Issa Naiem, Afifi Ladan, Jeon Caleb, Chang Hsin Wen, Liao Wilson
机构信息
Department of Dermatology, University of California-San Francisco, San Francisco, CA, USA.
Georgetown University, School of Medicine, Washington D.C., USA.
出版信息
Curr Dermatol Rep. 2017 Jun;6(2):94-103. doi: 10.1007/s13671-017-0178-5. Epub 2017 Apr 22.
Abstract
PURPOSE
To understand the changes in the microbiome in psoriatic disease, we conducted a systematic review of studies comparing the skin and gut microbiota in psoriatic individuals and healthy controls.
FINDINGS
Our review of studies pertaining to the cutaneous microbiome showed a trend towards an increased relative abundance of and a decreased level of in psoriasis patients compared to controls. In the gut microbiome, the ratio of and was perturbed in psoriatic individuals compared to healthy controls. was also relatively underrepresented in psoriasis patients relative to healthy individuals.
SUMMARY
Although the field of the psoriatic microbiome is relatively new, these first studies reveal interesting differences in microbiome composition that may be associated with the development of psoriatic comorbidities and serve as novel therapeutic targets.
摘要
目的
为了解银屑病疾病中微生物群的变化，我们对比较银屑病患者和健康对照者皮肤及肠道微生物群的研究进行了系统综述。
研究结果
我们对有关皮肤微生物群的研究综述显示，与对照组相比，银屑病患者中[具体微生物名称1]的相对丰度有增加趋势，而[具体微生物名称2]水平降低。在肠道微生物群中，与健康对照相比，银屑病患者中[具体微生物名称3]和[具体微生物名称4]的比例受到干扰。相对于健康个体，[具体微生物名称5]在银屑病患者中也相对较少。
总结
尽管银屑病微生物群领域相对较新，但这些初步研究揭示了微生物群组成中有趣的差异，这些差异可能与银屑病合并症的发生有关，并可作为新的治疗靶点。
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