Marquand Andre F, Haak Koen V, Beckmann Christian F
Radboud University Medical Centre, Kapittelweg 29, 6525 EN, Nijmegen, the Netherlands.
Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Kapittelweg 29, 6525 EN, Nijmegen, the Netherlands.
Nat Hum Behav. 2017 Aug;1(8):0146. doi: 10.1038/s41562-017-0146. Epub 2017 Jul 24.
Anatomical tracing studies in non-human primates have suggested that corticostriatal connectivity is topographically organized: nearby locations in striatum are connected with nearby locations in cortex. The topographic organization of corticostriatal connectivity is thought to underpin many goal-directed behaviours, but these topographies have not been completely characterised in humans and their relationship to uniquely human behaviours remains to be fully determined. Instead, the dominant approach employs parcellations that cannot model the continuous nature of the topography, nor accommodate overlapping cortical projections in the striatum. Here, we employ a different approach to studying human corticostriatal circuitry: we estimate smoothly-varying and spatially overlapping 'connection topographies' from resting state fMRI. These correspond exceptionally well with and extend the topographies predicted from primate tracing studies. We show that striatal topography is preserved in regions not previously known to have topographic connections with the striatum and that many goal-directed behaviours can be mapped precisely onto individual variations in the spatial layout of striatal connectivity.
对非人类灵长类动物的解剖学追踪研究表明，皮质纹状体连接是按拓扑结构组织的：纹状体内附近的位置与皮质内附近的位置相连。皮质纹状体连接的拓扑结构被认为是许多目标导向行为的基础，但这些拓扑结构在人类中尚未得到完全表征，它们与独特的人类行为之间的关系仍有待充分确定。相反，主流方法采用的脑区划分无法模拟拓扑结构的连续性，也无法容纳纹状体内重叠的皮质投射。在此，我们采用了一种不同的方法来研究人类皮质纹状体回路：我们从静息态功能磁共振成像中估计平滑变化且空间重叠的“连接拓扑结构”。这些与灵长类动物追踪研究预测的拓扑结构极为吻合，并对其进行了扩展。我们表明，纹状体拓扑结构在以前未知与纹状体有拓扑连接的区域中得以保留，并且许多目标导向行为可以精确地映射到纹状体连接空间布局的个体差异上。
