Pengo Vittorio, Bison Elisa, Banzato Alessandra, Zoppellaro Giacomo, Jose Seena Padayattil, Denas Gentian
Department of Cardiac, Thoracic and Vascular Sciences, Clinical Cardiology, Thrombosis Centre, University of Padova Medical School, via Giustiniani2, 35128, Padova, Italy.
Methods Mol Biol. 2017;1646:169-176. doi: 10.1007/978-1-4939-7196-1_14.
Diluted Russell Viper Venom Time (dRVVT) has become the most popular test to detect Lupus Anticoagulant (LA). dRVVT is more sensitive than other global tests employed to detect LA and is not affected by inhibitors of factor VIII or IX. The test is most successfully implemented if you observe three steps in its execution: screening, mixing, and confirmatory studies. Interference due to the presence of heparin in tested plasma must be excluded by means of thrombin time (TT). The prior use of Vitamin K Antagonists (VKAs) or Non-vitamin K Oral Anticoagulants (NOACs) must also be evaluated by means of International Normalized Ratio, or specific tests, respectively.
稀释蝰蛇毒时间（dRVVT）已成为检测狼疮抗凝物（LA）最常用的试验。dRVVT比用于检测LA的其他全血凝固试验更敏感，且不受因子VIII或IX抑制剂的影响。如果在执行该试验时遵循三个步骤：筛查、混合和确证性研究，那么该试验将最成功地实施。必须通过凝血酶时间（TT）排除受检血浆中肝素存在所导致的干扰。维生素K拮抗剂（VKA）或非维生素K口服抗凝药（NOAC）的既往使用情况也必须分别通过国际标准化比值或特定试验进行评估。
