Gosselin Robert C, Douxfils Jonathan
Department of Pathology and Laboratory Medicine, Davis Health System, University of California, 4400 V Street, Sacramento, CA, 95817, USA.
Department of Pharmacy, Namur Thrombosis and Hemostasis Center, Namur Research Institute for Life Sciences, University of Namur, Namur, Belgium.
Methods Mol Biol. 2017;1646:217-225. doi: 10.1007/978-1-4939-7196-1_18.
Direct oral anticoagulants (DOACs) can be quantified using methods that can be performed in any clinical or research laboratory using manual or automated instrument platforms. Dabigatran etexilate, the oral direct thrombin inhibitor, can be quantified by drug-calibrated clot or chromogenic-based assays using either thrombin or ecarin as substrates. Oral direct anti-Xa inhibitors, such as rivaroxaban, apixaban, and edoxaban, can be quantified with drug-calibrated anti-Xa kits or reagents as typically used for measuring heparins (unfractionated, low molecular weight, or pentasaccharides).
直接口服抗凝剂（DOACs）可以使用能够在任何临床或研究实验室通过手动或自动仪器平台进行的方法进行定量。口服直接凝血酶抑制剂达比加群酯，可以通过以凝血酶或蛇毒凝血酶为底物的药物校准凝血或基于显色的测定法进行定量。口服直接抗Xa因子抑制剂，如利伐沙班、阿哌沙班和依度沙班，可以使用通常用于测量肝素（普通肝素、低分子肝素或戊糖）的药物校准抗Xa试剂盒或试剂进行定量。
