Finnbogadóttir Sara K, Glintborg Dorte, Jensen Tina K, Kyhl Henriette B, Nohr Ellen A, Andersen Marianne
Department of Endocrinology, Odense University Hospital, Odense, Denmark.
Department of Environmental Medicine, Odense University Hospital, Odense, Denmark.
Acta Obstet Gynecol Scand. 2017 Nov;96(11):1307-1314. doi: 10.1111/aogs.13200. Epub 2017 Sep 20.
Polycystic ovary syndrome is associated with obesity and insulin resistance in the non-pregnant state, but little is known about insulin sensitivity in the pregnant state. Our objective was to compare insulin resistance in pregnant women with and without polycystic ovary syndrome and explore the impact of polycystic ovary syndrome on body composition in offspring at birth and at three years of age.
A prospective cohort study including 2548 live-born singleton mother-child pairs residing in Odense municipality, Denmark, during 2010-2013. Of the 2548 women, 241 (9.4%) had polycystic ovary syndrome.
Homeostatic model assessment for insulin resistance assessments were comparable in women with and without polycystic ovary syndrome. However, the subgroup of overweight women with polycystic ovary syndrome had significantly higher levels of homeostatic model assessment for insulin resistance than overweight women without polycystic ovary syndrome (mean ± 2 SD): 4.4 (3.1) vs. 3.6 (3.4), p = 0.004. Maternal polycystic ovary syndrome did not affect offspring birthweight after accounting for age. However, polycystic ovary syndrome, adjusted for maternal body mass index, was associated with increased body mass index at three years of age (mean ± 2 SD): 16.0 (2.2) vs. 15.7 (2.1) kg/m , p = 0.04.
In our cohort, maternal polycystic ovary syndrome was not associated with insulin resistance after correcting for body mass index and was not an independent predictor of offspring birthweight. However, both polycystic ovary syndrome and high maternal body mass index may increase risk of childhood obesity at three years of age.
多囊卵巢综合征与非孕期的肥胖和胰岛素抵抗相关，但孕期胰岛素敏感性方面所知甚少。我们的目的是比较患有和未患有多囊卵巢综合征的孕妇的胰岛素抵抗情况，并探讨多囊卵巢综合征对出生时及三岁时子代身体组成的影响。
一项前瞻性队列研究，纳入了2010年至2013年期间居住在丹麦欧登塞市的2548对单胎活产母婴对。在这2548名女性中，241名（9.4%）患有多囊卵巢综合征。
胰岛素抵抗评估的稳态模型评估在患有和未患有多囊卵巢综合征的女性中具有可比性。然而，患有多囊卵巢综合征的超重女性亚组的胰岛素抵抗稳态模型评估水平显著高于未患有多囊卵巢综合征的超重女性（均值±2标准差）：4.4（3.1）对3.6（3.4），p = 0.004。在考虑年龄因素后，母亲的多囊卵巢综合征并未影响子代出生体重。然而，在调整了母亲体重指数后，多囊卵巢综合征与三岁时体重指数增加相关（均值±2标准差）：16.0（2.2）对15.7（2.1）kg/m²，p = 0.04。
在我们的队列中，校正体重指数后母亲的多囊卵巢综合征与胰岛素抵抗无关，也不是子代出生体重的独立预测因素。然而，多囊卵巢综合征和母亲高体重指数均可能增加三岁时儿童肥胖的风险。
