Gonzalez J, Passantino G, Esnal A, Cuesta N, García Vera J A, Mechelli L, Saez A, García Marín J F, Tempesta M
Edificio de Institutos de Investigación, Micros Veterinaria SL. INDEGSAL, León, Spain.
Department of Veterinary Medicine, University of Bari, Valenzano, Italy.
Reprod Domest Anim. 2017 Dec;52(6):1093-1096. doi: 10.1111/rda.13034. Epub 2017 Aug 13.
An abortion outbreak occurred in a goat herd of Murciano-Granadina breed in Almeria Region in Spain where 80 pregnant females aborted. All bacteriological and parasitological examinations resulted negative, whereas virological investigations and real-time PCR assay showed the presence of Caprine alphaherpesvirus 1 DNA in the pathological specimens from aborted foetuses. Nucleotide sequence analysis revealed that the DNA was highly close related to the Swiss strain E-CH (99.7%) and a little less extent to the Italian BA.1 strain (99.4%). Histopathological examination revealed multifocal, well-circumscribed, 50- to 200-μm-diameter foci of coagulative necrosis in the liver, lungs and kidneys of three foetuses. In the periphery of the necrosis, there were frequently epithelial cells with the chromatin emarginated by large, round, amphophilic intranuclear viral inclusion bodies. The source of the infection in the herd could not clearly find out even some hypothesis were formulated. This seems to be the first report of an abortion outbreak due to Caprine alphaherpesvirus 1 in a goat herd in Spain.
西班牙阿尔梅里亚地区一群穆尔西亚-格拉纳迪纳品种的山羊发生了流产疫情，80只怀孕母羊流产。所有细菌学和寄生虫学检查结果均为阴性，而病毒学调查和实时聚合酶链反应检测显示，流产胎儿的病理标本中存在山羊α疱疹病毒1型DNA。核苷酸序列分析表明，该DNA与瑞士E-CH株高度密切相关（99.7%），与意大利BA.1株的相关性略低（99.4%）。组织病理学检查显示，三只胎儿的肝脏、肺和肾脏出现多灶性、边界清晰、直径50至200微米的凝固性坏死灶。在坏死灶周边，经常可见上皮细胞，其染色质被大的、圆形、嗜两性的核内病毒包涵体挤向边缘。尽管提出了一些假设，但仍无法明确找出该羊群中的感染源。这似乎是西班牙山羊群中首次因山羊α疱疹病毒1型导致流产疫情的报告。
